[HTML][HTML] Mossy cells of the dentate gyrus: Drivers or inhibitors of epileptic seizures?

A Kecskés, B Czéh, M Kecskés - … et Biophysica Acta (BBA)-Molecular Cell …, 2022 - Elsevier
… the net effect of MC activation to GCs is inhibitory or excitatory. The … of hippocampal excitation
and inhibition recruited by mossy cells. … Animal models of TLE confirmed that the two most …

Seizure-induced strengthening of a recurrent excitatory circuit in the dentate gyrus is proconvulsant

K Nasrallah, MA Frechou, YJ Yoon… - Proceedings of the …, 2022 - National Acad Sciences
… mechanism for early epileptogenesis involving BDNF within a … Mossy cells (MCs), excitatory
neurons in the dentate gyrus (… In contrast, in a chronic mouse model of TLE induced by KA …

Adaptive mossy cell circuit plasticity after status epilepticus

CR Butler, GL Westbrook, E Schnell - Journal of Neuroscience, 2022 - Soc Neuroscience
… that mossy cell outputs reorganize following seizures, increasing their net inhibitory effect in
… commissural projections of mossy cells to the contralateral dentate gyrus. This resulted in …

[HTML][HTML] Neuronal activity dynamics in the dentate gyrus during early epileptogenesis

F Berglind, A Boulot, A Gonzalez-Ramos, E Melin… - Epilepsy Research, 2023 - Elsevier
… of hyper-excitability in different animal models, but only a few … a potentially critical role for
excitatory mossy cells (MCs), a … the consequences on the development of spontaneous seizures

Double-Edged Mossy Cells in Temporal Lobe Epilepsy: Evil in the Early Stage Through a BDNF-Dependent Strengthening Dentate Gyrus Circuit

H Cheng, Q Lou, Y Wang, Z Chen - Neuroscience Bulletin, 2023 - Springer
… -resistant epilepsies, is characterized by abnormal recurrent excitatory activity originating …
and animal models of TLE, and the surviving MCs have been disclosed to play an anti-epileptic

Mossy Cells and Epileptogenesis: From Synaptic Strengthening to Seizures

AL Brewster - Epilepsy Currents, 2023 - journals.sagepub.com
… A mossy cell (MC) is a type of excitatory neuron that resides in the hilus of the dentate gyrus
… the extent of electrographic and behavioral seizures in mouse models of TLE. Some findings …

A role of dentate gyrus mechanistic target of rapamycin activation in epileptogenesis in a mouse model of posttraumatic epilepsy

D Guo, L Han, CM Godale, NR Rensing, SC Danzer… - …, 2024 - Wiley Online Library
… in dentate gyrus granule cells promotes neuronal death, mossy fiber sprouting, and PTE in
the controlled cortical impact (CCI) model of … Expression appeared to be limited to excitatory

[HTML][HTML] Increased dentate gyrus excitability in the intrahippocampal kainic acid mouse model for temporal lobe epilepsy

M Vergaelen, S Manzella, K Vonck, E Craey… - International Journal of …, 2024 - mdpi.com
… In the dentate gyrus (DG), there is a severe loss of inhibitory … that sprouted mossy fibers in
epileptic mice indeed form … To unmask such an effect, we could combine electrophysiology …

Activity-dependent LTP in the dentate gyrus promotes epileptic seizures

K Nasrallah, M Agustina Frechou, YJ Yoon, S Persaud… - bioRxiv, 2021 - biorxiv.org
Excitatory mossy cells (MCs) in the dentate gyrus of the … mouse model of chronic TLE play
an antiepileptic role 4 , these … has a pro-convulsant effect during early epilepsy, we first tested …

[HTML][HTML] Neuronal MeCP2 in the dentate gyrus regulates mossy fiber sprouting of mice with temporal lobe epilepsy

Y Chen, XL Wu, HB Hu, SN Yang, ZY Zhang… - Neurobiology of …, 2023 - Elsevier
… in animal models have revealed that MFS rewires the dentate gyrus (DG), creating de novo
recurrent excitatory … in the epileptic hippocampus, the causal role of sprouted mossy fibers in …