… iPSC-derived motor neurons from patients with ALS carrying hexanucleotide expansions in
C9ORF72… to derive a separate set of C9ORF72 and control motor neurons. Many individual -…

… The goal of the current study was to use a multi-omic approach to test whether a network-based
analysis would facilitate identification of early pathogenic events in C9 ALS where the …

… The goal of the current study was to use a multi-omic approach to investigate whether a
network-based analysis would facilitate identification of early pathogenic events in C9-ALS …

… The goal of the current study was to use a multi-omic approach to investigate whether a
network-based analysis would facilitate identification of early pathogenic events in C9-ALS …

… Our results reveal aberrant lipid metabolism in 17 ALS patient-… hESC- and iPSC-derived
oMN-like molecular patterns … two types of motor neurons of SOD1 A4V and C9ORF72 lines, we …

… Integrated analysis of CNVs and gene expression profiling … in the motor cortex of
sporadic ALS patients, we performed a … of motor neurons in both the motor cortex, brainstem …

… (iPS) cell lines, multi-omic data derived from iPS neurons and … employing iPS spinal neurons
from patients with C9orf72 ALS/… Non-ALS motor neuron disease (MND) included patients …

… sequencing (scRNA-seq) analysis to address these limitations. … , isogenic patient lines were
established from two C9orf72 ALS … Modeling sporadic ALS in iPSC-derived motor neurons …

… (iPS) cell lines, multi-omic data derived from iPS neurons and … iPS spinal neurons from
patients with C9orf72 ALS/ … foci in iPSC-derived motor neurons from ALS patients with a …

… In summary, we conducted a multiomics analysis of human iPSCs and iPSC-derived neurons,
integrating … impairment from patients carrying inherited GRN mutations. However, this …