GD2-targeting therapy: a comparative analysis of approaches and promising directions

J Philippova, J Shevchenko, S Sennikov - Frontiers in Immunology, 2024 - frontiersin.org
… In the field of cell therapy, allogeneic immunocompetent cells … It was shown that hu3F8
was 200-fold more effective in … BiAbs, the optimal option was to place the antigen and T-cell

Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma

K Straathof, B Flutter, R Wallace, N Jain… - Science Translational …, 2020 - science.org
… The expression cassette further included the RQR8 sort/“suicide” … engenders highly effective
complement-mediated cell killing (16). … An emerging observation in CAR-T cell therapy is …

[HTML][HTML] GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma–assessing tumor and T cell interaction

J Sujjitjoon, E Sayour, ST Tsao, M Uiprasertkul… - Translational …, 2021 - Elsevier
… treatments for RB highlight the need for new, safer, and more effective therapeutic options. …
T cell treatment alone may be unable to completely eradicate tumor cells due to tumor cell

The glycosphingolipid GD2 as an effective but enigmatic target of passive immunotherapy in children with aggressive neuroblastoma (HR-NBL)

U Rovigatti - Cancer Letters, 2021 - Elsevier
… 5.1 Chimeric Antigen Receptor T cell therapy is based on the principle of redirecting T cells
through … still appears to be insufficient and requires further optimization for GD2-CAR-Ts [62]. …

Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results

A Heczey, X Xu, AN Courtney, G Tian, GA Barragan… - Nature Medicine, 2023 - nature.com
… + CAR-NKT subset mediates more potent anti-tumor activity than … In a recent phase 1/2 trial
of GD2-targeting CAR-T cells, … , multi-dosing of cell therapeutics may be required in certain …

State of the art and perspectives of CAR-T cell therapy for neuroblastoma

D Lutskovich, A Meleshko, M Katsin - Cytotherapy, 2024 - Elsevier
… of CAR-T cell therapy for neuroblastoma has proven safe and … via two distinct CARs are
more effective than the classical in … , antibody selection and optimization to increase recognition …

[图书][B] Engineering and Evaluating Chimeric Antigen Receptor T Cell Potency Ex Vivo and In Vitro

NJ Piscopo - 2020 - search.proquest.com
… reach of CAR T cell therapy has increased with the advent of … modulate medium composition
in situ to optimize cell yields. … cloned a third generation GD2-targeting CAR sequence [162] …

Synthetic biology approaches for enhancing safety and specificity of CAR-T cell therapies for solid cancers

GC Russell, Y Hamzaoui, D Rho, G Sutrave, JS Choi… - Cytotherapy, 2024 - Elsevier
… other moieties to make the CARs more advanced and effective. … , highlighting the need for
further optimization of these systems. … The development of safer yet effective therapy options is …

[HTML][HTML] The affinity of antigen-binding domain on the antitumor efficacy of CAR T cells: Moderate is better

R Mao, W Kong, Y He - Frontiers in immunology, 2022 - frontiersin.org
… target toxicity, but also are more effective. We then reviewed the … Currently, there is no
available data on the optimal ABD … Chimeric antigen receptor-Glypican-3 T-cell therapy for …

Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors

M Righi, I Gannon, M Robson, S Srivastava… - Cancer Immunology …, 2023 - AACR
… dFab_CCRs is optimal to improve CAR T-cell expansion, … T-cell therapies, as well as
therapies based on other immune … Each individual DNA barcode cassette was created as DNA g…