… T cell treatment, which may be a major reason causing the exhaustion of CAR T cells. Increased
lysis potency by … A direct comparison study of GD2 targeting BsAb (Hu3F8 x anti CD3) vs …

… To explore an alternate target antigen for neuroblastoma CAR T-cell therapy, the authors …
antibody with optimal binding properties could translate into effective CAR T-cell therapy. To …

… an inducible caspase 9 suicidal gene cassette (iCasp9), has … more specific mAbs with
higher affinity for applications of mAb therapy and CART therapy, but also develop more effective …

… powerful means of screening, identifying, validating and correcting tumor targets. Recently,
CRISPR/Cas9 technology and CAR T-cell therapies … anti-CD70 CAR cassette into the TRAC …

… manipulated to enhance the potency of CAR T-cell therapy. To date, … A natural killer cell is
capable of appealing cytokine cassette … that a safer and more feasible protocol is needed [47]. …

… antigen receptor-modified T cell (CAR-T) therapy using CARs constructed from established
… determining regions were found to show optimal antigen-specific cytotoxicity and cytokine …

… that local delivery of IL-12 may be an effective adjuvant for CAR-T cell therapy for GBM. …
These data demonstrate that combined IL-12 and CAR-T cell therapy promotes an effective and …

… The consequences of strong T-cell recruitment and powerful … -specific inducible expression
cassettes, such as interleukin … , and melanoma, GD2-targeting immunotherapies are now …

… a constitutive or inducible expression cassette, leading to the … In order to further increase
the potency of CAR-T cell therapy, … to evaluate the therapeutic potential of GD2-targeting late-…

… As a result, they found that this approach led to a potent antitumor … strategy to be used
along with CAR T-cell therapy, as … with a lentiviral transgene cassette, which expressed a 4-…