… soluble factors that play a role preventing effective CAR T-cell therapy. We used these findings
to … Additional CARs optimized for low density antigen recognition replaced CD8 H/TM with …

… Optimum requirements for cell growth are provided by the … coupled with CAR T-cell treatment
will be more effective. Radio… for some more efficient and safe future therapies. Simultaneous…

… fundamental aspect of CAR T cell therapy in clinical practice. … and durable CAR T cell therapy
for immunocompetent hosts, … -P2A-puro cassette was replaced with a Thy1.1 cassette. For …

… therapy highlights the importance of GD2 targeting for … targeting that could allow for a more
effective maintenance therapy. … CAR-T cell therapy involves specific antigen receptors to be …

… more than 2-fold in the CAR(NAP) T-cell treatment group … The orientation of the nap cassette
was opposite to that of … The GD2-targeting single chain fragment (scFv) sequence (derived …

… killer (NK) cells has been faced as a safer alternative therapy [11, 12]. … a potent source for
CAR-NK cell therapy [37]. In this regard, CD19-CAR-ML NK cells treatment showed increased …

… of CAR T-cell therapies for solid tumors can be fulfilled. … We also found that the PYAP-only
CAR had optimized signaling … gating to find the safest and most effective antigens to target. …

… Therefore, these antigens may be potentially effective targets in CAR T cell mediated
therapy clinically. CAR-T cells with trivalent targets to EPHA2, HER2 and IL13Rα2 did show …

… ) are the most effective source of adoptive cell treatment so far… have developed the suicide
gene cassette into CAR-T design (… Another GD2 targeting CAR-T cells with CCR2b expression …

… observed strong HLA class I upregulation on the cell surface … out to develop a cell therapy
approach to specifically deliver … IL-2Rγ expression cassette to simulate T cell activation upon …