Landscape of circulating tumour DNA in metastatic breast cancer

AA Davis, S Jacob, L Gerratana, AN Shah, F Wehbe… - …, 2020 - thelancet.com
… The goals of the analysis were to identify the landscape of ctDNA across pathological
subtypes, to evaluate the prevalence of clinically actionable alterations, to compare blood and …

Association of circulating tumor DNA with disease-free survival in breast cancer: a systematic review and meta-analysis

C Cullinane, C Fleming, DP O'Leary… - JAMA network …, 2020 - jamanetwork.com
… as a prognostic marker can be applied to both early and metastatic breast cancer disease
as suggested by subgroup analysis in this study. Another potential benefit of ctDNA is that it …

[HTML][HTML] Circulating tumor DNA in neoadjuvant-treated breast cancer reflects response and survival

MJM Magbanua, LB Swigart, HT Wu, GL Hirst, C Yau… - Annals of …, 2021 - Elsevier
… serial circulating tumor DNA (ctDNA) testing for predicting pCR and risk of metastatic recurrence.
… In summary, our study shows promise that early response prediction by highly sensitive …

Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial

NC Turner, B Kingston, LS Kilburn… - The Lancet …, 2020 - thelancet.com
… The high sensitivity of ctDNA testing for tissue mutations calls into question the need … ctDNA
results, within the pretreated metastatic breast cancer patient population studied. This study

Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients

L Darrigues, JY Pierga, A Bernard-Tessier… - Breast Cancer …, 2021 - Springer
… early changes of circulating tumor DNA (ctDNA) levels … study were to evaluate the relationship
between ctDNA detection and variation from baseline (bsl) to D15 and D30 with the tumor

Current status of circulating tumor cells, circulating tumor DNA, and exosomes in breast cancer liquid biopsies

M Tellez-Gabriel, E Knutsen, M Perander - International Journal of …, 2020 - mdpi.com
… of ctDNA in breast cancer. There are two fundamental strategies to analyze ctDNA: (1)
Quantification of total cfDNA based on the notion that cancer cells release more DNA than healthy …

Circulating tumor DNA after neoadjuvant chemotherapy in breast cancer is associated with disease relapse

F Cailleux, E Agostinetto, M Lambertini… - JCO Precision …, 2022 - ascopubs.org
… Detection of circulating tumor DNA (ctDNA) after neoadjuvant … stage breast cancer may
allow for early detection of relapse. In this study, we analyzed ctDNA using a personalized, tumor-…

Assessing tumor heterogeneity using ctDNA to predict and monitor therapeutic response in metastatic breast cancer

F Ma, Y Guan, Z Yi, L Chang, Q Li… - … journal of cancer, 2020 - Wiley Online Library
… that tumor heterogeneity can be noninvasively assessed through circulating tumor DNA (ctDNA).14-…
treatment outcome using tumor heterogeneity in ctDNA of metastatic breast cancer. …

[HTML][HTML] Circulating breast-derived DNA allows universal detection and monitoring of localized breast cancer

J Moss, A Zick, A Grinshpun, E Carmon, M Maoz… - Annals of …, 2020 - Elsevier
Circulating tumor DNA (ctDNA), identified based on the presence of somatic mutations, can
… that breast DNA could be detected in the circulation of patients with metastatic breast cancer, …

Serial analysis of circulating tumor cells in metastatic breast cancer receiving first-line chemotherapy

MJM Magbanua, LH Hendrix, T Hyslop… - … the National Cancer …, 2021 - academic.oup.com
… that the detection of circulating tumor DNA (ctDNA) in blood is strongly associated with
poor prognosis (15,16). Contemporaneous analysis of CTCs and ctDNA in MBC have been …