Quantitative measures of crystalline fenofibrate in amorphous solid dispersion formulations by X-ray microscopy

JP Neilly, L Yin, SE Leonard, PJA Kenis… - … of Pharmaceutical …, 2020 - Elsevier
… and quantitative data analysis using basic image analysis tools. The technique is nondestructive,
Quantitation of crystalline fenofibrate consisted of counting the number of voxels with …

Surface characterization of pharmaceutical solids

A Kaur, DP Kale, AK Bansal - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
… In the current review, the analytical techniques have been … -point BET method for rapid
determination of SSA regardless … , deliquescence, amorphouscrystalline transformation and …

Identification and quantification techniques of polymorphic forms-A review

JT Chambi, C Fandaruff, SL Cuffini - Journal of Pharmaceutical and …, 2024 - Elsevier
solid-state techniques for detection and quantificationpharmaceutical products. Therefore,
in the context of monitoring and controlling polymorphism, the choice of analytical technique

Analytical techniques for structural characterization of proteins in solid pharmaceutical forms: An overview

A Bolje, S Gobec - Pharmaceutics, 2021 - mdpi.com
… (amorphous/crystalline) of lyophilized proteins. Moreover, recently developed methods
based on mass spectrometry, such as solid… it is difficult to perform quantification analysis [181,189]…

Solid-state analysis of amorphous solid dispersions: Why DSC and XRPD may not be regarded as stand-alone techniques

S Dedroog, T Pas, B Vergauwen, C Huygens… - … of Pharmaceutical and …, 2020 - Elsevier
phase behavior can refer to both amorphous-amorphous and amorphous-crystalline phase
… In this paper, we will highlight the two most commonly applied analytical techniques for solid-…

… , powder X-ray diffraction, and solid-state nuclear magnetic resonance spectroscopy for measuring crystallinity in amorphous solid dispersions-application to drug-in …

TW Jarrells, EJ Munson - Journal of Pharmaceutical Sciences, 2022 - Elsevier
… This work compared various analytical methods and techniques for quantifying endogenous
crystallinity in an ASD. Annealing-induced crystallinity was analyzed using various DSC, …

Characterization of amorphous solid dispersions and identification of low levels of crystallinity by transmission electron microscopy

M S'ari, H Blade, S Cosgrove… - … Pharmaceutics, 2021 - ACS Publications
… and has recently emerged as a useful analytical technique to study ASDs. Electron diffraction
and … scanning techniques to provide a more easily quantifiable measure of crystallization. …

Quantifying Micromolar Crystallinity in Pharmaceutical Materials Utilizing 19F Solid-State NMR

Y Du, P Phyo, M Li, B Sorman, M McNevin… - Analytical …, 2022 - ACS Publications
… LOD and the limit of quantification (LOQ) for analytical procedures that exhibit baseline noise,
respectively. Using this specification, the LOD and LOQ of the PXRD method in the current …

[HTML][HTML] Quantitative analysis of amorphous form in indomethacin binary polymorphic mixtures using infrared spectroscopy analytical techniques combined with …

M Liu, J Liu, Q Wang, P Song, H Li, Y Qin, S Wu… - Arabian Journal of …, 2023 - Elsevier
… In general, these two solid analysis techniques were suitable for the quantitative analysis of
… optimal quantitative model established by NIR analysis technology had lower LOD and LOQ …

A novel technique to characterize and quantify crystalline and amorphous matter in complex sugar mixtures

P Verma, NG Shah, SM Mahajani - Food Analytical Methods, 2020 - Springer
… In this article, we discuss the existing techniques and their … quantification of individual sugars
in the amorphous and crystalline forms will be discussed in detail. The proposed method is …