A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping

SJ Lusk, A McKinney, PJ Hunt, PG Fahey, J Patel… - BMC biology, 2022 - Springer
… has been broadly restricted to manipulations of a limited set … to our ability to deconstruct
neural circuits on multiple levels. … and functional in vivo characterization in respiratory control. …

Cre driver mouse lines for thalamocortical circuit mapping

G Sokhadze, PW Campbell… - Journal of …, 2022 - Wiley Online Library
neural circuits can be targeted in mice with genetic tools in a highly selective manner for
visualization and manipulation. … in thalamus suitable for both anatomical and functional studies. …

Molecular and anatomical characterization of parabrachial neurons and their axonal projections

JL Pauli, JY Chen, ML Basiri, S Park, ME Carter… - Elife, 2022 - elifesciences.org
… although the neuronal circuits involved are not well … of Cre- driver lines of transgenic mice
that have been used to activate virally delivered, Cre- dependent genes to manipulate neuron

[HTML][HTML] Cellular anatomy of the mouse primary motor cortex

R Muñoz-Castañeda, B Zingg, KS Matho, X Chen… - Nature, 2021 - nature.com
… processes, shaping the neural circuit dynamics underlying cognition … neuron types and
mapping multi-scale connectivity in the … cross-laboratory anatomical analysis platform comprising …

Genetic dissection of the glutamatergic neuron system in cerebral cortex

KS Matho, D Huilgol, W Galbavy, M He, G Kim, X An… - Nature, 2021 - nature.com
… organization and assembly of neural circuits of the cerebral … dissection of molecularly and
anatomically defined PT types. … and manipulation, from dense coverage to single-cell analysis

Characterization and manipulation of Corticothalamic neurons in associative cortices using Syt6‐Cre transgenic mice

LO Vaasjo, X Han, AN Thurmon… - Journal of …, 2022 - Wiley Online Library
… To visualize the topography of thalamic nuclei according to the density of large “driver-like”
varicosities labeled in the Syt6-Cre; Ai14 mice, we generated a heat-map representing the …

Advancements in the quest to map, monitor, and manipulate neural circuitry

JL Swanson, PS Chin, JM Romero… - … in Neural Circuits, 2022 - frontiersin.org
map of the mammalian brain requires anatomically tracing … driver mice, a critical tool in the
age of viral genetics. … unable to adequately characterize the function of neuronal populations, …

Generation and characterization of a cell type-specific, inducible Cre-driver line to study olfactory processing

A Koldaeva, C Zhang, YP Huang… - Journal of …, 2021 - Soc Neuroscience
… a transgenic mouse line that enables mitral cells to be specifically labeled or manipulated.
This … In addition to the anatomic traits, to assess the labeled cells functionally, we loaded a …

Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain

KM Targowska-Duda, D Peters, JL Marcus, G Zribi… - Pain, 2022 - journals.lww.com
mouse genetic model to identify neural circuits and neuronal … For TRAP2 mice used for
neural manipulation studies, mice … , we further characterized the functional/anatomical identity of …

[HTML][HTML] A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery

H Zheng, L López-Ferreras, JP Krieger, S Fasul… - Molecular …, 2022 - Elsevier
… Thus, the availability of a transgenic rat model for targeted analysis and manipulation of Gcg…
the BLA in both Gcg-Cre/tdTom rats and in GLU-Cre/tdRFP mice, we used RNAscope FISH …