[HTML][HTML] … receptor gain in circulating free DNA and splicing variant 7 in exosomes predict clinical outcome in CRPC patients treated with abiraterone and enzalutamide
… and plasma AR gene gain are associated with shorter progression-free (PFS) and overall
survival (OS) with abiraterone or enzalutamide … were also associated with a worse outcome in …
survival (OS) with abiraterone or enzalutamide … were also associated with a worse outcome in …
Prognostic impact of total plasma cell-free DNA concentration in androgen receptor pathway inhibitor–treated metastatic castration-resistant prostate cancer
… the ARPIs abiraterone acetate or enzalutamide. Elevated total … -derived DNA at baseline
had worse outcomes on hormonal … association between plasma cfDNA and clinical outcomes …
had worse outcomes on hormonal … association between plasma cfDNA and clinical outcomes …
[HTML][HTML] … plasma tumor DNA (ctDNA) correlates with PSA kinetics in metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone or enzalutamide
V Conteduca, C Casadei, E Scarpi, N Brighi… - Cancers, 2022 - mdpi.com
… DNA (ctDNA) fraction in plasma and androgen receptor (AR) copy number (CN) gain correlates
with worse outcomes… if plasma DNA analysis and AR status associates with PSA kinetics. …
with worse outcomes… if plasma DNA analysis and AR status associates with PSA kinetics. …
Circulating androgen receptor for prognosis and treatment selection in prostate cancer
V Conteduca, D Wetterskog… - European Urology …, 2021 - Elsevier
… , particularly AR copy number, in plasma DNA is a minimally … clinical outcome and resistance
to abiraterone/enzalutamide … for the association of AR status with outcome for men at …
to abiraterone/enzalutamide … for the association of AR status with outcome for men at …
[HTML][HTML] Plasma AR Copy Number Changes and Outcome to Abiraterone and Enzalutamide
G Gurioli, V Conteduca, C Lolli, G Schepisi… - Frontiers in …, 2020 - frontiersin.org
… : Plasma androgen receptor (AR) copy number (CN) status … was associated with resistance
to these therapies, both in pre- … This study evaluated 73 patients with sufficient plasma DNA …
to these therapies, both in pre- … This study evaluated 73 patients with sufficient plasma DNA …
[HTML][HTML] … ) germline variant and clinical outcomes in metastatic castration-resistant prostate cancer patients treated with abiraterone and enzalutamide: results from two …
DJ Khalaf, IM Aragón, M Annala, R Lozano… - Annals of …, 2020 - Elsevier
… this polymorphism is associated with outcomes for metastatic … adrenal androgens into the
androgen receptor (AR) ligands … , complete blood counts, plasma/serum biochemical panel, …
androgen receptor (AR) ligands … , complete blood counts, plasma/serum biochemical panel, …
A systematic review and meta-analysis on the predictive value of cell-free DNA–based androgen receptor copy number gain in patients with castration-resistant …
SH Tolmeijer, E Boerrigter, JA Schalken… - JCO Precision …, 2020 - ascopubs.org
… -based AR gain is associated with a worse response to ARSIs… Only the results for the
association between outcome and AR … strongly associated with an inferior response to …
association between outcome and AR … strongly associated with an inferior response to …
[HTML][HTML] Grade group system and plasma androgen receptor status in the first line treatment for metastatic castration resistant prostate cancer
MC Cursano, V Conteduca, E Scarpi, G Gurioli… - Scientific Reports, 2022 - nature.com
… and their impact on the clinical outcome of AR-directed drugs … abiraterone and enzalutamide
and is associated to worse OS … DNA was quantified by a spectrophotometer (Nanodrop ND-…
and is associated to worse OS … DNA was quantified by a spectrophotometer (Nanodrop ND-…
Androgen receptor genomic alterations and treatment resistance in metastatic prostate cancer
… copies) had significantly worse outcomes when treated with … -associated genomic changes
converge upon the AR gene … F877L mutation can convert enzalutamide and apalutamide …
converge upon the AR gene … F877L mutation can convert enzalutamide and apalutamide …
Cell-Free DNA Alterations in the AR Enhancer and Locus Predict Resistance to AR-Directed Therapy in Patients With Metastatic Prostate Cancer
… such as abiraterone and enzalutamide. Still, approximately … Can we predict resistance to
androgen receptor (AR)–… (CTCs) and its association with resistance to androgen receptor (AR)–…
androgen receptor (AR)–… (CTCs) and its association with resistance to androgen receptor (AR)–…