[HTML][HTML] … receptor gain in circulating free DNA and splicing variant 7 in exosomes predict clinical outcome in CRPC patients treated with abiraterone and enzalutamide

M Del Re, V Conteduca, S Crucitta, G Gurioli… - Prostate cancer and …, 2021 - nature.com
… and plasma AR gene gain are associated with shorter progression-free (PFS) and overall
survival (OS) with abiraterone or enzalutamide … were also associated with a worse outcome in …

Prognostic impact of total plasma cell-free DNA concentration in androgen receptor pathway inhibitor–treated metastatic castration-resistant prostate cancer

H Fettke, EM Kwan, P Bukczynska, N Ng… - European Urology …, 2021 - Elsevier
… the ARPIs abiraterone acetate or enzalutamide. Elevated total … -derived DNA at baseline
had worse outcomes on hormonal … association between plasma cfDNA and clinical outcomes

[HTML][HTML] … plasma tumor DNA (ctDNA) correlates with PSA kinetics in metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone or enzalutamide

V Conteduca, C Casadei, E Scarpi, N Brighi… - Cancers, 2022 - mdpi.com
DNA (ctDNA) fraction in plasma and androgen receptor (AR) copy number (CN) gain correlates
with worse outcomes… if plasma DNA analysis and AR status associates with PSA kinetics. …

Circulating androgen receptor for prognosis and treatment selection in prostate cancer

V Conteduca, D Wetterskog… - European Urology …, 2021 - Elsevier
… , particularly AR copy number, in plasma DNA is a minimally … clinical outcome and resistance
to abiraterone/enzalutamide … for the association of AR status with outcome for men at …

[HTML][HTML] Plasma AR Copy Number Changes and Outcome to Abiraterone and Enzalutamide

G Gurioli, V Conteduca, C Lolli, G Schepisi… - Frontiers in …, 2020 - frontiersin.org
… : Plasma androgen receptor (AR) copy number (CN) status … was associated with resistance
to these therapies, both in pre- … This study evaluated 73 patients with sufficient plasma DNA

[HTML][HTML] … ) germline variant and clinical outcomes in metastatic castration-resistant prostate cancer patients treated with abiraterone and enzalutamide: results from two …

DJ Khalaf, IM Aragón, M Annala, R Lozano… - Annals of …, 2020 - Elsevier
… this polymorphism is associated with outcomes for metastatic … adrenal androgens into the
androgen receptor (AR) ligands … , complete blood counts, plasma/serum biochemical panel, …

A systematic review and meta-analysis on the predictive value of cell-free DNA–based androgen receptor copy number gain in patients with castration-resistant …

SH Tolmeijer, E Boerrigter, JA Schalken… - JCO Precision …, 2020 - ascopubs.org
… -based AR gain is associated with a worse response to ARSIs… Only the results for the
association between outcome and AR … strongly associated with an inferior response to …

[HTML][HTML] Grade group system and plasma androgen receptor status in the first line treatment for metastatic castration resistant prostate cancer

MC Cursano, V Conteduca, E Scarpi, G Gurioli… - Scientific Reports, 2022 - nature.com
… and their impact on the clinical outcome of AR-directed drugs … abiraterone and enzalutamide
and is associated to worse OS … DNA was quantified by a spectrophotometer (Nanodrop ND-…

Androgen receptor genomic alterations and treatment resistance in metastatic prostate cancer

EM Kwan, AW Wyatt - The Prostate, 2022 - Wiley Online Library
… copies) had significantly worse outcomes when treated with … -associated genomic changes
converge upon the AR gene … F877L mutation can convert enzalutamide and apalutamide …

Cell-Free DNA Alterations in the AR Enhancer and Locus Predict Resistance to AR-Directed Therapy in Patients With Metastatic Prostate Cancer

HX Dang, PS Chauhan, H Ellis, W Feng… - JCO precision …, 2020 - ascopubs.org
… such as abiraterone and enzalutamide. Still, approximately … Can we predict resistance to
androgen receptor (AR)–… (CTCs) and its association with resistance to androgen receptor (AR)–…