Telmisartan/17β-estradiol mitigated cognitive deficit in an ovariectomized rat model of Alzheimer's disease: modulation of ACE1/ACE2 and AT1/AT2 ratio
NF Abdelkader, AM Abd El-Latif, MM Khattab - Life sciences, 2020 - Elsevier
… Ovariectomized rats showed cognitive impairment in Morris … angiotensin-converting enzyme
1/angiotensin 2/angiotensin … , and aorta of OVX rats after chronic E 2 replacement therapy. …
1/angiotensin 2/angiotensin … , and aorta of OVX rats after chronic E 2 replacement therapy. …
Angiotensin (1–7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older rats
… -inflammatory gene expression within the pre-frontal cortex, a … 24-month-old male F344/BN
rats after 8 days (acute) and 29 … to improved cognitive function including increased (1) …
rats after 8 days (acute) and 29 … to improved cognitive function including increased (1) …
[HTML][HTML] Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease
J Royea, P Martinot, E Hamel - Neurobiology of Disease, 2020 - Elsevier
… , anti-inflammatory, and cognitive benefits when … AngIV-treatment (T) improved cognitive
function in APP mice. … Whereas our results showed no cognitive benefits in WT mice following …
function in APP mice. … Whereas our results showed no cognitive benefits in WT mice following …
AT1 receptors: their actions from hypertension to cognitive impairment
H Wu, Q Sun, S Yuan, J Wang, F Li, H Gao… - Cardiovascular …, 2022 - Springer
… -angiotensin system in hypertension and cognitive impairment… R plays a vital role in the
development of neuro-inflammation… faster in wildtype male than female mice after systemic Ang-II …
development of neuro-inflammation… faster in wildtype male than female mice after systemic Ang-II …
… -peptide Angiotensin-(1–7) Mimic AVE 0991 attenuates delayed neurocognitive recovery after laparotomy by reducing neuroinflammation and restoring blood-brain …
X Mi, Y Cao, Y Li, Y Li, J Hong, J He, Y Liang… - Frontiers in Aging …, 2021 - frontiersin.org
… Ang-(1–7) was reported to ameliorate cognitive impairment and … rats after surgery, we
examined the hippocampal expression of the microglial activation marker CD11b, the inflammatory …
examined the hippocampal expression of the microglial activation marker CD11b, the inflammatory …
AT2R's (Angiotensin II Type 2 Receptor's) role in cognitive and cerebrovascular deficits in a mouse model of Alzheimer disease
J Royea, M Lacalle-Aurioles, LJ Trigiani… - …, 2020 - Am Heart Assoc
… 1A) deficits in APP mice following 4 months of intervention, … urged researchers to better
understand how ARBs decrease the … benefits on vascular function and inflammation, our results …
understand how ARBs decrease the … benefits on vascular function and inflammation, our results …
Oral formulation angiotensin-(1-7) therapy attenuates pulmonary and systemic damage in mice with emphysema induced by elastase
AC Bastos, GS Magalhães, JF Gregório, NA Matos… - Immunobiology, 2020 - Elsevier
… with Ang-(1-7) in mice with elastase-induced PE reduces inflammatory cytokine in the lung
… -(1-7) after lung injury induced by three instillations with elastase: (i) improved the locomotor …
… -(1-7) after lung injury induced by three instillations with elastase: (i) improved the locomotor …
Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets
J Royea, E Hamel - Geroscience, 2020 - Springer
… binds to MAS receptors, or angiotensin III, followed by AngIV by … anti-inflammatory and
antioxidant properties in various mouse … cognitive function in APP J20 mice, while possessing the …
antioxidant properties in various mouse … cognitive function in APP J20 mice, while possessing the …
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future
F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
… -inflammatory cytokines consequently lead to an excessive … manifestations of the disease
appear after a pre-symptomatic … Therefore, improved synapsis network function seems to be …
appear after a pre-symptomatic … Therefore, improved synapsis network function seems to be …
Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation
… , the role of angiotensin II (Ang II) and Ang II type 1 receptor (AT1… cognitive impairment have
been reported weeks after … consequences of systemic inflammation on brain function, at least …
been reported weeks after … consequences of systemic inflammation on brain function, at least …