… pivotal role in infections by coronaviruses and influenza viruses. … in H5N1-challenged mice,
confirming the role of ACE2 in H5N1-… Our hypotheses suggest that more protection should be …

… This protection was achieved by inactivating Ang II thus … , for instance, infection of avian
influenza H5N1 and H7N9. , … causes acute and often lethal respiratory failure and implies a …

… This study suggest that ACE-2 protects against lung … human ACE2 ameliorated avian
influenza H5N1 virus-induced … and infection showed altered ratio of ACE-1 to ACE-2. Although in …

… , vascular protection, … -II levels were elevated in H5N1- and H7N9-infected patients,
which was associated with the severity of lung injury and predicted fatal outcomes in H7N9-infected …

… axis mediated by angiotensin-converting enzyme 2 (ACE2) can … This paper will specifically
examine the organ protection of … -CoV infection leads to highly lethal pneumonia compared …

… H5N1 and H7N9 avian influenza viruses reduce the ACE2 … Furthermore, ACEI and ARB can
protect against RAS … -CoV-2 bind to membranes angiotensin converting enzyme 2 (ACE2) of …

… angiotensin-converting enzyme 2 (ACE2) receptors [2,3], is … II and the pulmonary damage
in patients infected with SARS-… [4,5] using ACE2 knockout mice showed that ACE2 protects …

… Reports suggested that near 1–3% of COVID‐19 cases have a fatal outcome. … SARS-CoV-1
infection or administration of its spike protein resulted in reduced expression of ACE2 in the …

… anti-inflammatory and anti-oxidant role protecting the lungs against ARDS and lethal avian …
and lethality of infection, at least in some cases. Infection with avian influenza A H5N1 virus in …

… used during avian H5N1 and 1918 influenza virus infections, … -dependent protection, or
immune-mediated destruction 58 . … the mouse lethal dose 50 (MLD 50 ) of SARS-CoV-2. Inclusion …