Ant Venom-Based Ceramide Therapy Is Effective Against Atopic Dermatitis In Vivo.
JM Leyva-Castillo, C Huang, P Baker… - Journal of Drugs in …, 2023 - europepmc.org
JM Leyva-Castillo, C Huang, P Baker, J Bacsa, RS Geha, JL Arbiser
Journal of Drugs in Dermatology: JDD, 2023•europepmc.orgBackground Atopic dermatitis (AD) is a common skin condition with relatively few therapeutic
alternatives. These include corticosteroids, which address inflammation but not
superinfection, and Januse kinase (JAK) inhibitors, which have a US Food and Drug
Administration (FDA) black box for potential carcinogenicity. Methods We demonstrate that
S14, a synthetic derivative of ant venom-derived solenopsin, has potent anti inflammatory
effects on the OVA murine model of atopic dermatitis. S14 has demonstrated prior activity in …
alternatives. These include corticosteroids, which address inflammation but not
superinfection, and Januse kinase (JAK) inhibitors, which have a US Food and Drug
Administration (FDA) black box for potential carcinogenicity. Methods We demonstrate that
S14, a synthetic derivative of ant venom-derived solenopsin, has potent anti inflammatory
effects on the OVA murine model of atopic dermatitis. S14 has demonstrated prior activity in …
Background
Atopic dermatitis (AD) is a common skin condition with relatively few therapeutic alternatives. These include corticosteroids, which address inflammation but not superinfection, and Januse kinase (JAK) inhibitors, which have a US Food and Drug Administration (FDA) black box for potential carcinogenicity.
Methods
We demonstrate that S14, a synthetic derivative of ant venom-derived solenopsin, has potent anti inflammatory effects on the OVA murine model of atopic dermatitis. S14 has demonstrated prior activity in murine psoriasis and has the benefit of ceramide anti-inflammatory effects without being able to be metabolized into proinflammatory sphingosine-1 phosphate.
Results
The efficacy of S14 accompanied by the induction of IL-12 suggests a commonality in inflammatory skin disorders, and our results suggest that pharmacological ceramide restoration will be broadly effective for inflammatory skin disease.
Conclusions
Solenopsin derivative S14 has anti-inflammatory effects in murine models of AD and psoriasis. This makes S14 a strong candidate for human use, and pre-IND studies are warranted. J Drugs Dermatol. 2023; 22 (10): 1001-1006 doi: 10.36849/JDD. 7308.
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