LEAP-2 counteracts ghrelin-induced food intake in a nutrient, growth hormone and age independent manner
J Lugilde, S Casado, D Beiroa, J Cuñarro… - Cells, 2022 - mdpi.com
… using rats and mice, we study fasting-induced food intake as … endogenous noncompetitive
ghrelin receptor antagonist [15], … GHR-antagonist also reported a decrease in food intake [30]. …
ghrelin receptor antagonist [15], … GHR-antagonist also reported a decrease in food intake [30]. …
Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity
… as an endogenous antagonist of the ghrelin receptor regulated by … to decrease food intake
in mice [66]. More knowledge on signaling pathways activated by ghrelin at ghrelin receptors …
in mice [66]. More knowledge on signaling pathways activated by ghrelin at ghrelin receptors …
[HTML][HTML] Metabolic insights from a GHSR-A203E mutant mouse model
LJ Torz, S Osborne-Lawrence, J Rodriguez, Z He… - Molecular …, 2020 - Elsevier
… GHSR antagonists [D-Lys-3]-GHRP-6 or JMV2959, reduced … and binge-like high-fat intake
in mice [17,18]. Administration … food intake responses to administered ghrelin. In a first set of …
in mice [17,18]. Administration … food intake responses to administered ghrelin. In a first set of …
The new mechanism of Ghrelin/GHSR-1a on autophagy regulation
MJ Yuan, T Wang - Peptides, 2020 - Elsevier
… control mice but not in mice that lacked GH receptors … neurons, and ghrelin receptor
antagonists block this effect. … activates AMPK cascade signal pathway to regulate food intake and …
antagonists block this effect. … activates AMPK cascade signal pathway to regulate food intake and …
Beta-hydroxybutyrate suppresses hepatic production of the ghrelin receptor antagonist LEAP2
S Holm, AS Husted, LJ Skov, TH Morville… - …, 2022 - academic.oup.com
… reduces food intake and growth hormone secretion in mice (… that the endogenous ghrelin
receptor antagonist and inverse … by BHB administration in mouse and murine hepatocytes, and …
receptor antagonist and inverse … by BHB administration in mouse and murine hepatocytes, and …
[HTML][HTML] Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice
S Stutte, J Ruf, I Kugler, H Ishikawa-Ankerhold… - Brain, Behavior, and …, 2021 - Elsevier
… signaling by applying its antagonist cyclosomatostatin (CSS). … completely rescued weight
loss and food consumption, while … ghrelin receptor (growth hormone secretagogue receptor or …
loss and food consumption, while … ghrelin receptor (growth hormone secretagogue receptor or …
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer
… Using an established mouse model of lung cancer, we find that cachexia is characterized
by reduced food intake, … Ana is a ghrelin receptor agonist that has been reported to induce …
by reduced food intake, … Ana is a ghrelin receptor agonist that has been reported to induce …
Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under …
A Lillo, J Lillo, I Raïch, C Miralpeix, F Dosrius… - Frontiers in Cellular …, 2021 - frontiersin.org
… but that was prevented upon preincubation with the ghrelin receptor antagonist (Figure 2D).
… -R1a receptor antagonists, which could offer a double benefit: (i) reduce food intake and (ii) …
… -R1a receptor antagonists, which could offer a double benefit: (i) reduce food intake and (ii) …
Ghrelin as an anti-sepsis peptide
… when treated with ghrelin receptor antagonists (55). … weight loss and reduced food intake
in mice. Continuous administration of ghrelin to these mice improved food intake and body …
in mice. Continuous administration of ghrelin to these mice improved food intake and body …
Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin
S Péraldi-Roux, M Bayle, C M'Kadmi, M Damian… - Biochemical …, 2022 - Elsevier
… Rat/mouse ghrelin for food intake experiments was from … The monomeric human ghrelin
receptor was expressed in E. … 6616 could antagonize the insulinostatic effect of ghrelin. To do …
receptor was expressed in E. … 6616 could antagonize the insulinostatic effect of ghrelin. To do …