Can natural products targeting EMT serve as the future anticancer therapeutics?

S Anwar, JA Malik, S Ahmed, VA Kameshwar, J Alanazi… - Molecules, 2022 - mdpi.com
natural compounds might have promised anti-cancer activity … in SK-OV-3 cells via modulating
miR-211 expression [86]. … -resistant colorectal cancer cells via inhibiting EMT via miRNA […

Targeting microRNAs with thymoquinone: a new approach for cancer therapy

M Homayoonfal, Z Asemi, B Yousefi - Cellular & Molecular Biology Letters, 2021 - Springer
… as an anti-cancer agent through modulating miRNAs. … ) and P38 MAPK are signal transduction
pathways that belong to … the cell cycle at G1 phase HCT116 colon cancer cell lines by the …

Natural products targeting the MAPK-signaling pathway in cancer: overview

A Shi, L Liu, S Li, B Qi - Journal of Cancer Research and Clinical …, 2024 - Springer
cancer therapeutics related to MAPK signal transduction are … in colorectal cancer cells and
increase cancer cell apoptosis, … is a natural phenolic compound with high anti-cancer activity

Anti-cancer activity of phytochemicals targeting hypoxia-inducible factor-1 alpha

BD Yun, SW Son, SY Choi, HJ Kuh, TJ Oh… - International Journal of …, 2021 - mdpi.com
… be upregulated via nitric oxide and signal transducer and activator of … cells [102], indicating
that curcumin modulates HIF-1α … of colorectal cancer cells [109]. Investigation of the level and …

… of Elaphoglossum paleaceum (Hook. & Grev.) sledge derived phloroglucinols in human hepatocellular carcinoma cells through potential transcriptional modulation of …

LM Ruiz Manriquez - repositorio.tec.mx
… 5-FU in two human colorectal cancer cell lines, HCT 116 and HT-… miRNAs and critical signal
transduction networks during HCC … miRNAs and their regulatory role in HCC via modulating

Garcinol—a natural histone acetyltransferase inhibitor and new anti-cancer epigenetic drug

P Kopytko, K Piotrowska, J Janisiak… - International Journal of …, 2021 - mdpi.com
… also deregulate expression of miRNAs involved in tumour … Epigenetics also plays an
important role in the modulation of … , HT-29 (human colon cancer cells), gastric cancer cells, oral …

Emerging evidence on the effects of plant-derived microRNAs in colorectal cancer: a review

WJ Zhang, YY Li, ZH Xiang, J Deng, W Li, QL Lin… - Food & Function, 2023 - pubs.rsc.org
… can be used as a potential anti-cancer agent. Moreover, the … Lactobacillus and Bifidobacterium
modulate apoptotic … the gastrointestinal tract through signal transduction from enteric …

Remodeling the epigenetic landscape of cancer—application potential of flavonoids in the prevention and treatment of cancer

W Jiang, T Xia, C Liu, J Li, W Zhang, C Sun - Frontiers in Oncology, 2021 - frontiersin.org
… of cancer cells in HCT-116 colon cancer cells and human … maintain normal Wnt signal
transduction in rat colonic epithelium after … of skin cancer, anthocyanidins were shown to modulate

Histone Modification of Colorectal Cancer by Natural Products

Z Geng, M Chen, Q Yu, S Guo, T Chen, D Liu - Pharmaceuticals, 2023 - mdpi.com
… Among them, epigenetic modulation by natural products … in the signal transduction machinery
and control of cell growth [… Curcumin, a natural compound derived from natural products of …

A review of anti-tumour effects of ginsenoside in gastrointestinal cancer

J Xu, Y Pan, Y Liu, S Na, H Zhou, L Li… - Journal of Pharmacy …, 2021 - academic.oup.com
… of anti-cancer effect of ginseng in gastrointestinal cancer was … C/EBPβ/NF-κB signal
transduction, and the study confirmed … of cancer cells via three human colorectal cancer cell lines (…