[HTML][HTML] Novel chronic wound healing by anti-biofilm peptides and protease

FS Ghoreishi, R Roghanian… - Advanced pharmaceutical …, 2022 - ncbi.nlm.nih.gov
… , activated proteases release heparin-binding epidermal growth factors (HB-EGF) and
amphiregulin, which have antimicrobial activity and are responsible for stimulating the expression …

Clinical translation of biofilm dispersal agents

W Redman, D Fleming, K Sauer… - Antibiofilm Strategies …, 2022 - Springer
DispersinB has also shown efficacy in some in vivo models (… agents do not have antimicrobial
activity themselves, but are … include wound topical agents and antibacterial therapies for …

Local Delivery of Anti-biofilm therapeutics

Z Harrison, L Pace, R Awais, JA Jennings - … and Advanced Antimicrobial …, 2020 - Springer
Dispersin B combined with broad spectrum antimicrobial peptide KSL-W as a wound gel
could have anti-biofilm activity and could increase antibiotic efficacy against biofilms (Fig. 9) […

Antimicrobial strategies for topical biofilm-based wound infections: past, present, and future

RK Thapa, JO Kim, J Kim - Journal of Pharmaceutical Investigation, 2023 - Springer
wound healing. Further developments in prospective strategies for topical anti-biofilm therapy
for infected wounds … modalities, based on intrinsic antimicrobial activity, light-induced ROS …

Inhibitory effect of a KSL-W peptide-loaded poloxamer 407-based microemulsions for buccal delivery on Fusobacterium nucleatum biofilm

J Bernegossi, CR Fontana, KS Caiaffa… - Journal of …, 2020 - ingentaconnect.com
Antibiofilm and antimicrobial efficacy of dispersin B®-KSL-W peptide-based wound gel against
chronic wound … gene expression modulation by antimicrobial decapeptide KSL-W, BMC …

Dissecting the therapeutic potency of antimicrobial peptides against microbial biofilms

P Gupta, P Mishra, R Prasad… - Current Protein and …, 2021 - ingentaconnect.com
… , their mode of action, and anti-biofilm activity both alone and in … possess microbe specific
antimicrobial activity li e inhibition … However, peptide-based treatment of biofilm infections is li …

[HTML][HTML] Bioactive antimicrobial peptides as therapeutic agents for infected diabetic foot ulcers

J Da Silva, EC Leal, E Carvalho - Biomolecules, 2021 - mdpi.com
wound gel combining DispersinB ® , an antibiofilm enzyme, with Pluronic F-127, a gelling
agent, and KSL-W… in vitro antibiofilm and antimicrobial activity against chronic wound infection …

[HTML][HTML] Aggregatibacter actinomycetemcomitans Dispersin B: The Quintessential Antibiofilm Enzyme

JB Kaplan, SA Sukhishvili, M Sailer, K Kridin… - Pathogens, 2024 - mdpi.com
… efficient in enhancing the antibacterial efficiency of tobramycin. … [60], silver [103], the
antimicrobial peptide KSL-W [83], and a … that dispersin B combined with a silver wound dressing

Antimicrobial Peptides for Diabetic Wound Healing: Preclinical and Clinical Studies

A Herman, AP Herman - Advances in Wound Care, 2023 - liebertpub.com
… to have antimicrobial and antibiofilm activity against multiple … wound dressing materials
showed antibacterial activity … , 48 while KSL-W peptide solution and DispersinB ® -KSL-W

Poly-β-(1→6)-N-acetyl-D-glucosamine mediates surface attachment, biofilm formation, and biocide resistance in Cutibacterium acnes

JB Kaplan, C Cywes-Bentley, GB Pier… - Frontiers in …, 2024 - frontiersin.org
… We also found that dispersin B exhibited antibiofilm activities against C. acnes strains
HL036PA1 and HL043PA1 including inhibition of surface attachment (Figures 3–6) and …