Ecology and evolution of antibiotic persistence

L Verstraete, B Van den Bergh, N Verstraeten… - Trends in …, 2022 - cell.com
… can also survive antibiotic attack by adopting a tolerant phenotype. In the case of persistence,
only a small fraction within an isogenic population switches to this antibiotic-tolerant state. …

Antibiotic tolerance

LF Westblade, J Errington, T Dörr - PLoS pathogens, 2020 - journals.plos.org
… The same may apply to the recently described S-cells [24], which again may be … Highly
tolerant Escherichia coli cells that persist in the presence of the β-lactam ampicillin (“…

Antibiotic tolerance and persistence have distinct fitness trade-offs

C Michaux, S Ronneau, RT Giorgio, S Helaine - Plos Pathogens, 2022 - journals.plos.org
… in the population, antibiotic persistence and tolerance have distinct fitness trade-offs. Our data
show that antibiotic persistence is a … cells are all kept in the same recalcitrant state. Even if …

Evolution of bacterial tolerance under antibiotic treatment and its implications on the development of resistance

JE Sulaiman, H Lam - Frontiers in microbiology, 2021 - frontiersin.org
tolerance detection, as the tolerant population may readily be killed with another antibiotic,
whereas continued treatment with the same … that increase tolerance or persistence fraction …

Antibiotic resistance and persistence—Implications for human health and treatment perspectives

…, S Mairpady Shambat, SD Brugger, AS Zinkernagel - EMBO …, 2020 - embopress.org
… We describe the relationship between antibiotic persistence … bacterial persistence and
tolerance with the evolution of antibiotic … of antibiotics, which are fatal to other strains of the same

When antibiotics fail: a clinical and microbiological perspective on antibiotic tolerance and persistence of Staphylococcus aureus

…, S Meylan, J Mensa, A Soriano - … of Antimicrobial …, 2020 - academic.oup.com
… a small fraction of a population (named persisters) exhibit a tolerant … is not clear, we will
use the term ‘increased antibiotic survival’ 19 , 20 to encompass both tolerance and persistence. …

Evolutionary causes and consequences of bacterial antibiotic persistence

E Bakkeren, M Diard, WD Hardt - Nature Reviews Microbiology, 2020 - nature.com
… We review how some aspects of antibiotic persistence have been directly … antibiotic (this
means that persistence and tolerance are the same if 100% of the population is persistent

Tolerance and Persistence of Pseudomonas aeruginosa in Biofilms Exposed to Antibiotics: Molecular Mechanisms, Antibiotic Strategies and Therapeutic …

A Soares, K Alexandre, M Etienne - Frontiers in microbiology, 2020 - frontiersin.org
… cells, so that non-antibiotic alternative strategies are currently under development. … in antibiotic
tolerance and persistence in P. aeruginosa biofilm infections. A review of the antimicrobial

Link between antibiotic persistence and antibiotic resistance in bacterial pathogens

W Eisenreich, T Rudel, J Heesemann… - Frontiers in cellular and …, 2022 - frontiersin.org
… Figure 1 Formation of the antibiotic-tolerant persistence state (according to our hypothesis).
(… that bacteriostatic antibiotics, recognizing the same primary targets as BCAs, do not trigger …

Phenotypic heterogeneity in persisters: a novel 'hunker'theory of persistence

J Urbaniec, Y Xu, Y Hu… - FEMS microbiology …, 2022 - academic.oup.com
as tolerance or dormancy. In this review we focus on ‘antibiotic persistence’ which we broadly
define as a … important aspect of persistence: it is not the same for all antibiotics. Although …