Systems pharmacology modeling identifies a novel treatment strategy for bortezomib-induced neuropathic pain

P Bloomingdale, C Meregalli, K Pollard… - Frontiers in …, 2022 - frontiersin.org
… and prevented bortezomib-induced mechanical allodynia and … Anti-TNFα antibodies have
shown to prevent allodynia in … that were significantly decreased in a rat model of BIPN (Figure 5…

[HTML][HTML] The actions and mechanisms of P2X7R and p38 MAPK activation in mediating bortezomib-induced neuropathic pain

Y Guo, X Xu, J Huang, Z Wang, Z Li, Z Liu - BioMed research …, 2020 - hindawi.com
decrease through the expression of tumor necrosis factor-α (TNF… In the present study, a BIPN
rat model was established and used … with allodynia rat model was successfully established. …

[HTML][HTML] Inhibition of microRNA-155 reduces neuropathic pain during chemotherapeutic bortezomib via engagement of neuroinflammation

Z Duan, J Zhang, J Li, X Pang, H Wang - Frontiers in Oncology, 2020 - frontiersin.org
… of pro−inflammatory tumor necrosis factor-α receptor (TNFR1) in … Using this rat model, a recent
study showed that blocking … mechanical allodynia and thermal hyperalgesia in BTZ rats. In …

[HTML][HTML] Bortezomib-induced peripheral neuropathy: clinical features, molecular basis, and therapeutic approach

Y Yang, B Zhao, H Lan, J Sun, G Wei - Critical Reviews in Oncology …, 2024 - Elsevier
… Although next-generation PIs result in a lower incidence rate … 3; TNF-α,tumor necrosis
factor-α; TRPA1, transient receptor … and/or allodynia) is a common feature in BIPN models, the …

L-and T-type Ca2+ channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma

HN Wang, WJ Qian, GL Zhao, F Li… - Neural Regeneration …, 2023 - journals.lww.com
… ganglion cells were reduced in a rat model of chronic ocular … mediate the effects of tumor
necrosis factor-α. TUNEL assays … The primary antibodies used in this study were mouse anti-…

BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis

H Ding, J Chen, M Su, Z Lin, H Zhan, F Yang… - Journal of …, 2020 - Springer
… of exogenous BDNF further decreased the mechanical … ), interleukin-6 (IL-6), and tumor
necrosis factor-α (TNF-α), etc. [11, … ; in our CYP-induced cystitis rat model, the neurons received …

Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A3 Receptor Subtype

E Coppi, F Cherchi, E Lucarini, C Ghelardini… - International Journal of …, 2021 - mdpi.com
… the mechanical allodynia induced by different rat models of … GABA decrease and preventing
mechanical allodynia (Figure 2B… of response to bortezomib-induced hyperalgesia in females …

[PDF][PDF] Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in osteoarthritis model rats

M Niibori, Y Kudo, T Hayakawa, K Ikoma-Seki… - Heliyon, 2020 - cell.com
Tumor necrosis factor-α (TNF-α) is upregulated in … or activity reduced thermal hyperalgesia
and mechanical allodynia [… In bortezomib-induced painful peripheral neuropathy model, TNF-…

Multiple myeloma—a painful disease of the bone marrow

M Diaz-delCastillo, AD Chantry, MA Lawson… - Seminars in Cell & …, 2021 - Elsevier
Tumour necrosis factor α … Moreover, these treatments also reduced the overexpression of
neuronal excitation … Animal models of bortezomib-induced peripheral neuropathy include mice …

[HTML][HTML] Cannabinoids: an effective treatment for chemotherapy-induced peripheral neurotoxicity?

G Cavaletti, P Marmiroli, CL Renn, SG Dorsey… - …, 2021 - Elsevier
… Administration of CP55,940 decreased the migration of rat … Among the different forms of
CIPN, bortezomib-induced … Here we briefly report the results of a study performed in a rat model