Systems pharmacology modeling identifies a novel treatment strategy for bortezomib-induced neuropathic pain
P Bloomingdale, C Meregalli, K Pollard… - Frontiers in …, 2022 - frontiersin.org
… and prevented bortezomib-induced mechanical allodynia and … Anti-TNFα antibodies have
shown to prevent allodynia in … that were significantly decreased in a rat model of BIPN (Figure 5…
shown to prevent allodynia in … that were significantly decreased in a rat model of BIPN (Figure 5…
[HTML][HTML] The actions and mechanisms of P2X7R and p38 MAPK activation in mediating bortezomib-induced neuropathic pain
Y Guo, X Xu, J Huang, Z Wang, Z Li, Z Liu - BioMed research …, 2020 - hindawi.com
… decrease through the expression of tumor necrosis factor-α (TNF… In the present study, a BIPN
rat model was established and used … with allodynia rat model was successfully established. …
rat model was established and used … with allodynia rat model was successfully established. …
[HTML][HTML] Inhibition of microRNA-155 reduces neuropathic pain during chemotherapeutic bortezomib via engagement of neuroinflammation
Z Duan, J Zhang, J Li, X Pang, H Wang - Frontiers in Oncology, 2020 - frontiersin.org
… of pro−inflammatory tumor necrosis factor-α receptor (TNFR1) in … Using this rat model, a recent
study showed that blocking … mechanical allodynia and thermal hyperalgesia in BTZ rats. In …
study showed that blocking … mechanical allodynia and thermal hyperalgesia in BTZ rats. In …
[HTML][HTML] Bortezomib-induced peripheral neuropathy: clinical features, molecular basis, and therapeutic approach
Y Yang, B Zhao, H Lan, J Sun, G Wei - Critical Reviews in Oncology …, 2024 - Elsevier
… Although next-generation PIs result in a lower incidence rate … 3; TNF-α,tumor necrosis
factor-α; TRPA1, transient receptor … and/or allodynia) is a common feature in BIPN models, the …
factor-α; TRPA1, transient receptor … and/or allodynia) is a common feature in BIPN models, the …
L-and T-type Ca2+ channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma
HN Wang, WJ Qian, GL Zhao, F Li… - Neural Regeneration …, 2023 - journals.lww.com
… ganglion cells were reduced in a rat model of chronic ocular … mediate the effects of tumor
necrosis factor-α. TUNEL assays … The primary antibodies used in this study were mouse anti-…
necrosis factor-α. TUNEL assays … The primary antibodies used in this study were mouse anti-…
BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis
H Ding, J Chen, M Su, Z Lin, H Zhan, F Yang… - Journal of …, 2020 - Springer
… of exogenous BDNF further decreased the mechanical … ), interleukin-6 (IL-6), and tumor
necrosis factor-α (TNF-α), etc. [11, … ; in our CYP-induced cystitis rat model, the neurons received …
necrosis factor-α (TNF-α), etc. [11, … ; in our CYP-induced cystitis rat model, the neurons received …
Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A3 Receptor Subtype
E Coppi, F Cherchi, E Lucarini, C Ghelardini… - International Journal of …, 2021 - mdpi.com
… the mechanical allodynia induced by different rat models of … GABA decrease and preventing
mechanical allodynia (Figure 2B… of response to bortezomib-induced hyperalgesia in females …
mechanical allodynia (Figure 2B… of response to bortezomib-induced hyperalgesia in females …
[PDF][PDF] Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in osteoarthritis model rats
M Niibori, Y Kudo, T Hayakawa, K Ikoma-Seki… - Heliyon, 2020 - cell.com
… Tumor necrosis factor-α (TNF-α) is upregulated in … or activity reduced thermal hyperalgesia
and mechanical allodynia [… In bortezomib-induced painful peripheral neuropathy model, TNF-…
and mechanical allodynia [… In bortezomib-induced painful peripheral neuropathy model, TNF-…
Multiple myeloma—a painful disease of the bone marrow
M Diaz-delCastillo, AD Chantry, MA Lawson… - Seminars in Cell & …, 2021 - Elsevier
… Tumour necrosis factor α … Moreover, these treatments also reduced the overexpression of
neuronal excitation … Animal models of bortezomib-induced peripheral neuropathy include mice …
neuronal excitation … Animal models of bortezomib-induced peripheral neuropathy include mice …
[HTML][HTML] Cannabinoids: an effective treatment for chemotherapy-induced peripheral neurotoxicity?
G Cavaletti, P Marmiroli, CL Renn, SG Dorsey… - …, 2021 - Elsevier
… Administration of CP55,940 decreased the migration of rat … Among the different forms of
CIPN, bortezomib-induced … Here we briefly report the results of a study performed in a rat model …
CIPN, bortezomib-induced … Here we briefly report the results of a study performed in a rat model …