Antiproliferative Activity of a New Quinazolin-4(3H)-One Derivative via Targeting Aurora Kinase A in Non-Small Cell Lung Cancer

JY Lee, H Yang, D Kim, KZ Kyaw, R Hu, Y Fan, SK Lee - Pharmaceuticals, 2022 - mdpi.com
… , is a potential target for … (3H)-one derivative, BIQO-19, with improved solubility and
pharmacokinetic properties and which exhibits increased antiproliferative activity against cancer

Synthesis and antibacterial activities of quinazolin-4 (3h)-one, 2-methyl-4 (3h)-quinazolinone and 2–phenyl-4 (3h)-quinazolinone

PO Osarumwense, MO Edema, CO Usifoh - International Journal of …, 2021 - ijbpsa.com
derivatives, quinazolin-4(3H)-One, 2-Methyl4(3H)-quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one
4(3H)-quinazolinone ring system have showed antitumor, anticonvulsant, …

Computational insights into the reaction mechanism of the synthesis of quinazoline derivatives via the cyclocondensation reaction between methyl 2-amino-4-(2 …

AP Tenambo, AI Adjieufack, MB Ewonkem… - Computational and …, 2024 - Elsevier
… (3H)-one mainly rely on the Niementowski reaction, which uses the cyclization of anthranilic
acid or its derivatives … reactions by formation of C single bond C or N single bond C bond as …

Molecular hybridization as a strategy for developing artemisinin-derived anticancer candidates

E Marchesi, D Perrone, ML Navacchia - Pharmaceutics, 2023 - mdpi.com
… of artemisinin-derived hybrids with potential anticancer activity. The synthetic … derivatives
with the synthetic anticancer tamoxifen and sulfasalazine drugs are also reported. Table 1

Design and Synthesis of 3,6-Disubstituted- and 2,3,6-Trisubstitutedquinoxalines: Docking and In Vitro Antimicrobial Study

MMF Ismail, HMA El-Sehrawi, MM Khalifa… - Polycyclic Aromatic …, 2022 - Taylor & Francis
… Citation 1 Many quinoxaline derivatives have been reported … is disclosing potent antibacterial,
anticancer and antiviral activities. … The potentially active antimicrobial compounds from the …

Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents

RE Khidre, IAM Radini - Scientific reports, 2021 - nature.com
… a good to excellent yield from the reaction of 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)…
, and 2,3-dichloroquinoxaline, respectively. The potential DNA gyrase inhibitory activity was …

Recent advances in the synthesis and utility of thiazoline and its derivatives

S Kumar, A Arora, S Sapra, R Kumar, BK Singh… - RSC …, 2024 - pubs.rsc.org
… Numerous thiazoline derivatives exhibit anticancer properties, encompassing a range of …
explored for their intriguing therapeutic potential, encompassing anti-cancer properties, anti-…

Heterocyclic Scaffolds in Novel Synthetic Antibacterial Agents

BK Tiwary, K Pradhan - Alternatives to Antibiotics: Recent Trends and …, 2022 - Springer
… biological activities especially antitumor and antibacterial ones, … The quinazoline-4(3H)-one
and its derivatives constitute an … study, 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones …

One-pot synthesis of novel fused mesoionic compounds: 1-substituted-5-thioxo-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazolin-1-ium-2-thiolates

SM Kovalenko, OG Drushlyak… - Journal of Sulfur …, 2020 - Taylor & Francis
… Quinazolin-4(3H)-one derivatives are in abundance among … So, the introduction at the 3
position, an arylideneamino … )-ones [Citation26] show promising antitumor activity. Against …