[HTML][HTML] Chronic intermittent convection-enhanced delivery of vigabatrin to the bilateral subthalamic nucleus in an acute rat seizure model

D MacKeigan, M Feja, M Gernert - Epilepsy Research, 2024 - Elsevier
… -STN transplantation of GABAergic cells induced … Anticonvulsant effects after grafting of
rat, porcine, and human mesencephalic neural progenitor cells into the rat subthalamic nucleus

[HTML][HTML] Acute and chronic convection-enhanced muscimol delivery into the rat subthalamic nucleus induces antiseizure effects associated with high responder rates

M Gernert, D MacKeigan, L Deking, E Kaczmarek… - Epilepsy research, 2023 - Elsevier
… adverse effects, and (d) restricted drug distribution within the … seizure threshold (ivPTZ-ST)
model, we included acute … 2000) after unilateral microinjection of muscimol into the STN …

[HTML][HTML] Not part of the temporal lobe, but still of importance? Substantia nigra and subthalamic nucleus in epilepsy

S Bröer - Frontiers in Systems Neuroscience, 2020 - frontiersin.org
… transient anticonvulsant effects of neurotransplantation into … and inoperable epilepsy, who
received unilateral, chronic, high … persistence of cell transplantation into seizure propagation …

Interneuron Transplantation for Drug-Resistant Epilepsy

DG Southwell - Neurosurgery Clinics, 2024 - neurosurgery.theclinics.com
… , interneuron transplantation has been found to improve seizure phenotypes and associated
behavioral abnormalities in rodent models of focal and generalized epilepsy. Stem cell

[HTML][HTML] Current Status and Potential Challenges of Cell-Based Therapy for Treating Status Epilepticus and Chronic Epilepsy

H Zhao, Z Li - Epilepsy-Update on Classification, Etiologies …, 2020 - intechopen.com
… have chronic seizures due to resistant to antiepileptic drugs [41… transplantation of
GABA-producing cells into subthalamic … of GABA-producing cells into the STN suppressed seizure

[HTML][HTML] Bypassing the blood–brain barrier: direct intracranial drug delivery in epilepsies

M Gernert, M Feja - Pharmaceutics, 2020 - mdpi.com
… observed anticonvulsant effects in the acute flurothyl seizure model. … only unilaterally in this
study, although bilateral intranigral … , a cell transplantation study also indicated that bilateral

[HTML][HTML] Long-lasting antiseizure effects of chronic intrasubthalamic convection-enhanced delivery of valproate

D MacKeigan, M Feja, S Meller, L Deking… - Neurobiology of …, 2023 - Elsevier
seizure initiation and propagation, the subthalamic nucleus (… /catheter system in a rat seizure
model aiming to confirm an … was excluded due to a unilateral lesion of the STN identified …

[HTML][HTML] Stem cell therapy in treating epilepsy

BL Chang, KH Chang - Frontiers in neuroscience, 2022 - frontiersin.org
model of temporal lobe epilepsy, transplanting NSCs into the hippocampus appears responsive
effects on seizuremodels are acute seizure models that can be used to evaluate the …

Interneuron transplantation: a prospective surgical therapy for medically refractory epilepsy

SC Harward, DG Southwell - Neurosurgical Focus, 2020 - thejns.org
… B, Bröer S, Löscher W, Gernert M: Anticonvulsant effects by bilateral and unilateral
transplantation of GABA-producing cells into the subthalamic nucleus in an acute seizure model. …

Stem cells: A path towards improved epilepsy therapies

ZR Lybrand, S Goswami, J Hsieh - Neuropharmacology, 2020 - Elsevier
… state of “epilepsy-in-a-dish” models and discuss potential … rat brains into the adult epileptic
animal was anticonvulsant, … is that MGE transplants may ameliorate seizures by increasing …