Maintaining rapid antidepressant effects following ketamine infusion: a major unmet need

GI Papakostas - The Journal of Clinical Psychiatry, 2020 - psychiatrist.com
… of intranasal esketamine for treatment-resistant depression—a … gains of intravenous ketamine
for major depressive disorder. A … To date, several randomized controlled trials8-13 have …

Pharmacological treatments for patients with treatment-resistant depression

VL Ruberto, MK Jha, JW Murrough - Pharmaceuticals, 2020 - mdpi.com
… Over a third of patients with major depressive disorder (MDD… as HAM-D for detecting
antidepressant efficacy [90]. Another … not know how many randomized control trials (RCTs) …

Adjunctive intranasal esketamine for major depressive disorder: a systematic review of randomized double-blind controlled-placebo studies

W Zheng, DB Cai, YQ Xiang, WL Jiang, K Sim… - Journal of Affective …, 2020 - Elsevier
… However, ketamine in the treatment of depression required … Efficacy of esketamine nasal
spray plus oral antidepressanttreatment-resistant depression: a randomized clinical trial

Ketamine and Transcranial Magnetic Stimulation in an Adolescent with Treatment-Resistant Depression

AU Jerath, SE Oldak, MS Parrish, M Zaydlin… - Journal of Child and …, 2023 - liebertpub.com
Antidepressant efficacy of ketamine in treatment-resistant major depression: A two-site
randomized controlled trial… Comparison of long-term efficacy and safety of esketamine nasal spray …

[HTML][HTML] … integrative approach to ketamine therapy may enhance multiple dimensions of efficacy: improving therapeutic outcomes with treatment resistant depression

SA Muscat, G Hartelius, CR Crouch… - Frontiers in Psychiatry, 2021 - frontiersin.org
… of treatment resistant major depressive disorder received one … of the antidepressant
effectiveness of ketamine. This theory … studies, of which 60 were included: 20 randomized control

A comparison of the safety, feasibility, and tolerability of ECT and ketamine for treatment-resistant depression

A Tamman, A Anand, SJ Mathew - Expert Opinion on Drug Safety, 2022 - Taylor & Francis
… trajectory of depression, as severe depression often emerges in … Of the controlled studies
that have been done, cases of … If the ongoing RECOVER randomized controlled blinded trial […

Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis

ATH Kwan, KM Teopiz, S Wong, JD Rosenblat… - Journal of Affective …, 2024 - Elsevier
… on randomized controlled trials (RCTs) of ketamine treatment … ketamine with a newly initiated
oral antidepressant. Of the placebos used in the control group, less than half of the studies

High-dose Versus Low-dose Oral Ketamine on Control and Relapse of Treatment-resistant Depression: A Randomized, Double-blinded Clinical Trial

G KheirAbadi, S Golkar - Iranian Journal of Psychiatry and Behavioral …, 2023 - brieflands.com
… preclinical evidence represented the potential antidepressant effect of ketamine due to its
N-… neuronal synaptoplasticity and improving baseline clinical depressive symptoms (20). …

[HTML][HTML] Ketamine in major depressive disorder: mechanisms and future perspectives

C Shin, YK Kim - Psychiatry investigation, 2020 - ncbi.nlm.nih.gov
… A series of recent randomized controlled trials have provided … may be required to maintain
antidepressant efficacy. Moreover, … treatment-resistant depression: a randomized clinical trial. …

Time to relapse after a single administration of intravenous ketamine augmentation in unipolar treatment-resistant depression

NC Salloum, M Fava, RS Hock, MP Freeman… - Journal of affective …, 2020 - Elsevier
randomized controlled trials (RCT) confirming the acute and robust antidepressant effect of
a single infusion of ketamine … of Ketamine plus Scopolamine in major depressive disorder (…