… In addition, the upregulation of antioxidant signals such as … HO-1 protects cells from ROS
and raises ferritin levels to … signaling can control Nrf2-mediated antioxidant gene expression via …

… apoptosis in PC12 cells via upregulation of HO-1 expression [127]. … The antioxidant potential
of lariciresinol (103) is due to the … of antioxidant enzymes by activating Nrf2-mediated HO-1 …

… activity of the (+)-lariciresinol enantiomer extracted from Rubia … upregulation of the Nrf2-ARE
axis, which leads to expression of … Lari and SDG target Nrf2-mediated expression of HO-1. …

… Pinoresinol varies from 73 to 423 μg/day while lariciresinol … DNA oxidation, increasing
tissues antioxidant enzyme capacity by … , upregulation of PI3K/AKT signaling, upregulating HO-1 …

… HO-1) expression … antioxidant properties, reducing ROS production in RAW 264.7 cells,
and raising the translation and transcriptional rates of antioxidant enzymes with stimulating HO-1 …

… induces HO-1, which has well-known antioxidant properties … the expression of the Nrf2
protein, which limits Nrf2-mediated … More importantly, the upregulated HO-1 level and inhibited …

… We found that lariciresinol and isopimpinellin yielded high … suggested lariciresinol’s
significant antioxidant properties, … role in activating Nrf2-mediated HO-1 expression, a crucial …

… Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol,
a lignan isolated from Rubia philippinensis, through the activation of p38. Sci. Rep., 2017…

… In the present study, the protective effect of lariciresinol, a … lariciresinol in a
concentration-dependent manner prevented the accumulation of collagen by reducing the protein …

… metabolism (secoisolariciresinol, lariciresinol, and pinoresinol), … effect via NRF2-mediated
HO-1 activation including MAPK … the upregulation of HO-1, SOD, the GSH-related antioxidant …