Apixaban for treatment of embolic stroke of undetermined source (ATTICUS) randomized trial–update of patient characteristics and study timeline after interim analysis

S Poli, C Meissner, HJ Baezner, A Kraft… - European Heart …, 2021 - academic.oup.com
oral factor Xa inhibitor apixaban, started within 28 days after index stroke, is superior to
aspirin in preventing new … Primary endpoint was detection of new ischemic lesions in flair and …

Use and outcomes of prothrombin complex concentrate for factor Xa inhibitor-associated bleeding

AK Frank, P Ganesan, A Thompson… - Thrombosis …, 2021 - thrombosisresearch.com
Factor Xa (fXa) inhibitors such as rivaroxaban and apixaban are becoming the anticoagulants
of … Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. …

Quality evaluation of case series describing four-factor prothrombin complex concentrate in oral factor Xa inhibitor-associated bleeding: A systematic review

OS Costa, WL Baker, Y Roman-Morillo… - BMJ open, 2020 - bmjopen.bmj.com
… in patients treated with rivaroxaban or apixaban compared to warfarin presenting with major
… . New oral anticoagulants: their advantages and disadvantages compared with vitamin K …

[HTML][HTML] Rivaroxaban versus apixaban for treatment of cancer-associated venous thromboembolism in patients at lower risk of bleeding

KS Caroti, C Becattini, M Carrier, AT Cohen… - TH Open, 2023 - thieme-connect.com
… research and has been determined by the New England Institutional Review Board to be …
to our interpretation that these two oral factor Xa inhibitors have similar effectiveness and safety…

[HTML][HTML] Safety, pharmacokinetics and exploratory exposure-response analysis of CX3002, a novel inhibitor of Xa, in Chinese healthy subjects

W Chen, Z Ruan, H Lou, L Wang, R Shao, F Li… - European Journal of …, 2023 - Elsevier
… of CX3002 and apixaban on venous thrombosis in New Zealand … difference between CX3002
and apixaban on thrombosis of … measurement of direct factor Xa inhibitors: anti-Xa assay is …

Transitioning to Unfractionated Heparin in Treatment of Non-ST-Segment Elevation Myocardial Infarction Patients on Direct Oral Anti-Xa Inhibitors

M Tashani, RA Stevens… - Cellular and Molecular …, 2023 - cellmolbiol.org
… , several new oral agents that selectively target Factor Xa … of direct oral anticoagulants (DOACs),
rivaroxaban, apixaban, … of DOACs with factor Xa inhibitory effects, including apixaban, …

[HTML][HTML] Increased bleeding events with the addition of apixaban to the dual anti-platelet regimen for the treatment of patients with acute coronary syndrome: a meta …

J Jin, X Zhuo, M Xiao, Z Jiang, L Chen, YD Shamloll - Medicine, 2021 - journals.lww.com
… ] Apixaban, another non-vitamin K antagonist, is a new oral … Addition of the novel oral
anti-coagulant apixaban to DAPT in … , [30] works by inhibiting factor Xa of the coagulation cascade, …

Rivaroxaban, a direct oral factor Xa inhibitor, attenuates atherosclerosis by alleviating factor Xa–PAR2-mediated autophagy suppression

Y Ito, Y Maejima, S Nakagama… - Basic to Translational …, 2021 - jacc.org
… We evaluated the impact of RIV, a direct oral factor Xa inhibitor, … the aggravation of
atherosclerosis induced by factor Xa. … by blocking the factor Xa–PAR2-mediated inhibition of …

Evaluation of anti-Xa apixaban and rivaroxaban levels with respect to known doses in relation to major bleeding events

SN Nguyen, MC Ruegger, E Salazar… - Journal of …, 2022 - journals.sagepub.com
… available calibrators of the various Xa inhibitors, and our apixaban and rivaroxaban assays
are calibrated … In emergent situations, expert opinion recommends antidote administration at …

Warfarin faring better: Vitamin K antagonists beat rivaroxaban and apixaban in the INVICTUS and PROACT Xa trials

JW Eikelboom, JI Weitz - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
… black box warning against the use of dabigatran, and oral factor Xa inhibitors are not …
generation of sufficient amounts of factor Xa to overwhelm apixaban. This concept is supported …