Do TUNEL and other apoptosis assays detect cell death in preclinical studies?

R Mirzayans, D Murray - International Journal of Molecular Sciences, 2020 - mdpi.com
… Herein, we briefly review: (i) stress-induced responses that are associated with persistent
genomic DNA breakage and thus might be detected by the TUNEL assay (Section 2); (ii) …

Apoptosis (programmed cell death) and its signals-A review

E Obeng - Brazilian Journal of Biology, 2020 - SciELO Brasil
Apoptosis is therefore said to be crucial from the point of development of an embryo … This
review seeks to elaborate on the recent overview of the mechanism involved in apoptosis, …

The concept of intrinsic versus extrinsic apoptosis

L Lossi - Biochemical Journal, 2022 - portlandpress.com
… In this review, I will first discuss the most common types of regulated cell death on a … Yet,
I will briefly discuss below the main morphological features of the better-known types of …

Intratumor heterogeneity and therapy resistance: Contributions of dormancy, apoptosis reversal (anastasis) and cell fusion to disease recurrence

R Mirzayans, D Murray - International journal of molecular sciences, 2020 - mdpi.com
… In this article we briefly discuss the dark sides of dormancy, apoptosis, and cell fusion in …
In this article, we provided a brief review of the ever-growing complexity of cancer cell response …

BCL-w: apoptotic and non-apoptotic role in health and disease

ML Hartman, M Czyz - Cell Death & Disease, 2020 - nature.com
… either cell survival or apoptosis. The balance between pro-survival and pro-apoptotic
proteins is … This review discusses current knowledge on the role of BCL-w in health, non-cancerous …

Apoptosis, pyroptosis, and necroptosis—Oh my! The many ways a cell can die

N Ketelut-Carneiro, KA Fitzgerald - Journal of molecular biology, 2022 - Elsevier
… of the dying cell are contained within apoptotic bodies. In this review, we focus on the three
… We briefly describe each pathway before comparing their similarities and differences. We …

[HTML][HTML] Multiple cell death modalities and their key features

GE Yan, M Elbadawi, T Efferth - World …, 2020 - build.spandidos-publications.com
… categorized as apoptotic cell death or non‑apoptotic cell … apoptotic cell death is mostly
characterized by membrane rupture and caspase-independency. For simplicity, the present review

[HTML][HTML] From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways

Y Wang, TD Kanneganti - Computational and structural biotechnology …, 2021 - Elsevier
apoptosis and/or necroptosis that cannot be accounted for by any of these PCD pathways
alone… In this review, we provide a brief overview of the research history of pyroptosis, apoptosis

Clinical review: navitoclax as a pro-apoptotic and anti-fibrotic agent

NN Mohamad Anuar, NS Nor Hisam, SL Liew… - Frontiers in …, 2020 - frontiersin.org
… A brief description of their mechanism in modulating the intrinsic apoptotic pathway is …
mechanism in regulating cell apoptosis through other families of apoptotic protein not only through …

Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues

S Kumari, R Dhapola, DHK Reddy - Apoptosis, 2023 - Springer
… pro-apoptotic factors resulting in dysregulation of apoptosis. Drugs … This study sheds light
on apoptotic pathways that are cardinal … These have a brief prodomain and are processed and …