Mitochondrial reactive oxygen species enhance alveolar macrophage activity against Aspergillus fumigatus but are dispensable for host protection

N Shlezinger, TM Hohl - MSphere, 2021 - Am Soc Microbiol
… 2 regulated conidial uptake and killing by alveolar macrophages in … Aspergillus interactions
stimulate mtROS production in lung … In this work, pharmacologic inhibition of the macrophage

Antifungal Effect of All-trans Retinoic Acid against Aspergillus fumigatus In Vitro and in a Pulmonary Aspergillosis In Vivo Model

E Campione, R Gaziano, E Doldo… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
… Retinoids are key modulators of cell growth, differentiation, and apoptosisAlveolar
macrophages are the first important line of the host’s immune defense against Aspergillus conidia

Phagolysosomal Survival Enables Non-lytic Hyphal Escape and Ramification Through Lung Epithelium During Aspergillus fumigatus Infection

C Seidel, SD Moreno-Velásquez… - Frontiers in …, 2020 - frontiersin.org
… phagocytes, like alveolar macrophages, have been … or intracellularly during its interaction
with the lung epithelia. Continuous … apoptosis or preventing the oxidative stress responses of …

Bacterial Interactions with Aspergillus fumigatus in the Immunocompromised Lung

A Margalit, JC Carolan, K Kavanagh - Microorganisms, 2021 - mdpi.com
fumigatus growth and biofilms by inducing fungal apoptosis [95,96]. … aeruginosa can inhibit
the growth of A. … fumigatus conidia revealed antagonistic interactions resulting in the bacteria …

TRAF3 gene regulates macrophage migration and activation by lung epithelial cells infected with Aspergillus fumigatus

S Shang, D He, C Liu, X Bao, S Han… - Microbiology …, 2024 - Am Soc Microbiol
… into lung epithelial cell-macrophage interactions during A. … Lung epithelial cells and alveolar
macrophages coexist in … live or heat-killed Aspergillus fumigatus ΔsglA Conidia fully protects …

[HTML][HTML] A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis

G Goldman, C Valero, C Pinzan, P de Castro… - Research …, 2023 - ncbi.nlm.nih.gov
… that upon conidial phagocytosis, AspA is already interacting with proteins at the macrophage
… 8M urea in 25 mM AB containing protease inhibitor cocktail using a probe tip sornicator: 40…

Dexamethasone Creates a Suppressive Microenvironment and Promotes Aspergillus fumigatus Invasion in a Human 3D Epithelial/Immune Respiratory Model

MK Luvanda, W Posch, A Noureen, E Lafon, V Zaderer… - Journal of Fungi, 2021 - mdpi.com
… to infections is subject to interactions between the epithelial … fumigatus, when pre-treated
with Dexamethasone over a 1-… The ability of such cocultures to inhibit the transition of conidia

Murine Intraepithelial Dendritic Cells Interact With Phagocytic Cells During Aspergillus fumigatus-Induced Inflammation

AO Bogorodskiy, EL Bolkhovitina, T Gensch… - Frontiers in …, 2020 - frontiersin.org
… Internalization of conidia by alveolar macrophages promotes conidiaapoptotic neutrophils
from swarming clusters that we supposedly observed in the present study evidently inhibited

Involvement of JNK signaling in Aspergillus fumigatus-induced inflammatory factors release in bronchial epithelial cells

X Cui, F Chen, J Zhao, D Li, M Hu, X Chen, Y Zhang… - Scientific Reports, 2023 - nature.com
fumigatus conidia interact with airway epithelial cells and initiate the activation of … Lung
macrophages inhibited growth of A. fumigatus conidia by secreting inflammatory cytokines and …

Neutrophil and macrophage NADPH oxidase 2 differentially control responses to inflammation and to Aspergillus fumigatus in mice

RA Idol, S Bhattacharya, G Huang, Z Song… - The Journal of …, 2022 - journals.aai.org
alveolar macrophage NOX2 is a nonredundant effector that limits germination of inhaled A.
fumigatus conidia… In the clinical setting, there are many variables that can interact and lead to …