[HTML][HTML] Analyzing the opportunities to target DNA double-strand breaks repair and replicative stress responses to improve therapeutic index of colorectal cancer

PP Tomasini, TN Guecheva, NM Leguisamo, S Pericart… - Cancers, 2021 - mdpi.com
… second leading cause of cancer-related deaths worldwide. The 5… Genetic instability in MSI
tumors, known to result from … can also form simple deletions and apparent blunt-end junctions […

[HTML][HTML] Beyond the double-strand breaks: the role of DNA repair proteins in cancer stem-cell regulation

J Nathansen, F Meyer, L Müller, M Schmitz… - Cancers, 2021 - mdpi.com
… large genes cognitively often correlates with CFS instability. … stemness program might not be
obvious. Yet, accumulating … expression of a breast cancer-related mutant leads to increased …

[HTML][HTML] METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability

H Li, C Wang, L Lan, L Yan, W Li, I Evans… - Cellular and Molecular …, 2022 - Springer
… is a major problem that leads to the failure of clinical treatments. … tumors being the third
leading cause of cancer-related … was proven to have obvious CSC characteristics and oxaliplatin …

[HTML][HTML] Theranostic interpolation of genomic instability in breast cancer

R Rasool, I Ullah, B Mubeen, S Alshehri… - International Journal of …, 2022 - mdpi.com
… DNA replication errors accompanying an increased duplication rate … relevant to cancer are
not obvious. PARPi is generally well … It also could help in identifying cancer-related genes and …

Strategic enhancement of immune checkpoint inhibition in refractory Colorectal Cancer: Trends and future prospective

N Liu, F Shan, M Ma - International Immunopharmacology, 2021 - Elsevier
… second leading cause of cancer related mortality worldwide. … of cancers can be divided into
microsatellite instability and … antitumor activity and no obvious toxicity were observed when …

Structural variation in cancer: role, prevalence, and mechanisms

MR Cosenza, B Rodriguez-Martin… - … and Human Genetics, 2022 - annualreviews.org
… oncogenic effects on cancer-related gene expression are … whole-genome duplication are
more genomically unstable and at … genetic loci, typically amplified oncogenes, which are visible

The fragility of a structurally diverse duplication block triggers recurrent genomic amplification

R Suzuki, MM Murata, N Manguso… - Nucleic Acids …, 2021 - academic.oup.com
… ,25), although the retarded growth is evident. Thus, the essentiality of … To test the instability,
we set to define the relative fragility of … -1, that flank cancer-related genes such as ERBB2 and …

[HTML][HTML] Loss of MMR and TGFBR2 increases the susceptibility to microbiota-dependent inflammation-associated colon cancer

E Tosti, AS Almeida, TTT Tran, MB e Silva… - Cellular and Molecular …, 2022 - Elsevier
… second leading cause for cancer-related mortality in the United … DNA sequences, termed
microsatellite instability (MSI). In … -α staining was evident when comparing CRCs with SI tumors (…

[图书][B] New immunotherapy strategies and related therapeutic targets for gastrointestinal malignancies

CC Wong, Y Tian, C Sun, Q Zhao, G Ramamoorthi… - 2024 - books.google.com
… was positively correlated with microsatellite instability (MSI) and … of cells to repair DNA
replication errors and thereby leads to … incidence and 35% of all cancer-related deaths (1). Current …

Germline genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes

X Xu, Y Zhou, X Feng, X Li, M Asad, D Li, B Liao… - Science …, 2020 - science.org
… with oncogenesis- and genome instability–related mutations. … that the important cancer-related
information is implicated in … patients, we observed a visible subset with VAF ranging from …