[HTML][HTML] The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment
S Li, L Wang, Y Wang, C Zhang, Z Hong… - Journal of Hematology & …, 2022 - Springer
… very large genes, and inducing viral integration, cancer-related stress, and … instability [30].
Taken together, these results indicate that due to repeated DNA sequences, some replication …
Taken together, these results indicate that due to repeated DNA sequences, some replication …
[HTML][HTML] Repetitive DNA sequence detection and its role in the human genome
… Furthermore, HERVs and mammalian apparent LTR … These unstable repeats are found in
up to 20% of eukaryotic genes and … of the repeat region and subsequent gene duplication. This …
up to 20% of eukaryotic genes and … of the repeat region and subsequent gene duplication. This …
[HTML][HTML] Relative telomere length change in colorectal carcinoma and its association with tumor characteristics, gene expression and microsatellite instability
… Telomere shortening and selected group of cancer related genes: In … We found overexpression
of DNA replication genes both in … Telomere shortening was more noticeable in low-grade …
of DNA replication genes both in … Telomere shortening was more noticeable in low-grade …
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
… R-loop accumulation and its associated genome instability, we … 3f); 257 regions showed
apparent lower R-loop content in … Cancer-related information for SWI/SNF genes was retrieved …
apparent lower R-loop content in … Cancer-related information for SWI/SNF genes was retrieved …
[HTML][HTML] Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells
… cancer-related pathways following telomere attrition. … We speculate that sufficient replication
time with increasing passages … and tissues do not show evident changes in the transcription …
time with increasing passages … and tissues do not show evident changes in the transcription …
[HTML][HTML] Aberrant HMGA2 Expression Sustains Genome Instability That Promotes Metastasis and Therapeutic Resistance in Colorectal Cancer
R Campos Gudino, KJ McManus, S Hombach-Klonisch - Cancers, 2023 - mdpi.com
… of aberrations in cancer-related genes provides subpopulations of … HMGA2 stabilizes arrested
replication forks to protect them from … This HMGA2 protective effect is particularly evident at …
replication forks to protect them from … This HMGA2 protective effect is particularly evident at …
[HTML][HTML] BAP1 as a guardian of genome stability: implications in human cancer
… of BAP1 in many cancer-related biological activities, strongly … of BAP1 in DNA repair and
replication, which are crucial for … The BAP1 phosphorylation mutant exhibited no apparent …
replication, which are crucial for … The BAP1 phosphorylation mutant exhibited no apparent …
G-quadruplex DNA: A novel target for drug design
FY Teng, ZZ Jiang, M Guo, XZ Tan, F Chen… - Cellular and Molecular …, 2021 - Springer
… Usually, the loop size has a significant impact on the stability … DNA replication origins are
required for replication initiation … derivative could cause obvious downregulation of BCL-2 …
required for replication initiation … derivative could cause obvious downregulation of BCL-2 …
[HTML][HTML] Extrachromosomal circular DNA (eccDNA): an emerging star in cancer
… We highlight the possible cancer-related applications of … The d-TMP is helpful for gene
replication, leading to instability and … It is obvious that eccDNA accumulates largely in aging cells, …
replication, leading to instability and … It is obvious that eccDNA accumulates largely in aging cells, …
[HTML][HTML] A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
T Egger, B Bordignon, A Coquelle - Scientific Reports, 2022 - nature.com
… cancer-related deaths worldwide. By interfering with the DNA … Moreover, around 40% of
CRCs with microsatellite instability … also failed to induce any noticeable difference in the post-…
CRCs with microsatellite instability … also failed to induce any noticeable difference in the post-…