[HTML][HTML] The genome stability maintenance DNA helicase DDX11 and its role in cancer

M Mahtab, A Boavida, D Santos, FM Pisani - Genes, 2021 - mdpi.com
replication stress is played by the so-called fork-protection … Lung cancer is the most common
cause of cancer-related … phase melanoma and found evident morphological alterations, …

[HTML][HTML] Evolution, structure and emerging roles of C1ORF112 in DNA replication, DNA damage responses, and cancer

J Edogbanya, D Tejada‐Martinez, NJ Jones… - Cellular and Molecular …, 2021 - Springer
… superfamily of repetitive structures in which the repeating unit, … with cancerrelated genes
[3]. To be more precise, mouse … regulation, maintaining genomic stability and normative DNA …

[HTML][HTML] BAP1 as a guardian of genome stability: implications in human cancer

J Kwon, D Lee, SA Lee - Experimental & Molecular Medicine, 2023 - nature.com
… of BAP1 in many cancer-related biological activities, strongly … of BAP1 in DNA repair and
replication, which are crucial for … The BAP1 phosphorylation mutant exhibited no apparent

[HTML][HTML] Aberrant HMGA2 Expression Sustains Genome Instability That Promotes Metastasis and Therapeutic Resistance in Colorectal Cancer

R Campos Gudino, KJ McManus, S Hombach-Klonisch - Cancers, 2023 - mdpi.com
… of aberrations in cancer-related genes provides subpopulations of … HMGA2 stabilizes arrested
replication forks to protect them from … This HMGA2 protective effect is particularly evident at …

Biomarkers of genome instability in normal mammalian genomes following drug‐induced replication stress

S Minocherhomji, Y Liu, YD He… - Environmental and …, 2020 - Wiley Online Library
… water and stored at 4C, protected from light, until use. The dose … three major categories:
cancer-related pathways, immune … RPA2) was evident following drug-induced replication stress. …

[HTML][HTML] Repetitive DNA sequence detection and its role in the human genome

X Liao, W Zhu, J Zhou, H Li, X Xu, B Zhang… - Communications …, 2023 - nature.com
… Furthermore, HERVs and mammalian apparent LTR … These unstable repeats are found in
up to 20% of eukaryotic genes and … of the repeat region and subsequent gene duplication. This …

[HTML][HTML] Genome maintenance in retinoblastoma: Implications for therapeutic vulnerabilities

C Lee, JK Kim - Oncology letters, 2022 - spandidos-publications.com
… stalling of replication forks prevalently at repetitive regions of … NGS approach on cancer-related
gene panels led to the … mechanisms to protect and maintain genome stability from the …

[HTML][HTML] MYBL2-driven transcriptional programs link replication stress and error-prone DNA repair with genomic instability in lung adenocarcinoma

BB Morris, NA Wages, PA Grant, PT Stukenberg… - Frontiers in …, 2021 - frontiersin.org
… -associated genes or genes that govern replication fork protection … Lung cancer is the leading
cause of cancer related deaths … widespread replication stress, which was evident given the …

Telomere-related markers for cancer

X Yuan, M Dai, D Xu - Current topics in medicinal chemistry, 2020 - ingentaconnect.com
… cap at the end of chromosomes to maintain genomic stability … , however, the replicationinduced
telomere shortening in … in the regions of cancer-related genes including TERT [87]. …

Exploiting replication stress as a novel therapeutic intervention

JC Martin, TJ Hoegel, ML Lynch, A Woloszynska… - Molecular Cancer …, 2021 - AACR
… Cancer is the leading cause of cancer-related death in … genomic and chromosomal instability
from replication stress arises … This has obvious consequences including changes in gene