Timing Genetic Events in Tumours with Chromosomal Instability

TM Baker - 2024 - discovery.ucl.ac.uk
… Furthermore, I demonstrate that a genome duplication is … learning to identify repeated
sequences of somatic events … , with a majority of cancer-related deaths attributable to metastatic …

Theranostic interpolation of genomic instability in breast cancer

R Rasool, I Ullah, B Mubeen, S Alshehri… - International Journal of …, 2022 - mdpi.com
genes, many of which are involved in stalled replication fork … relevant to cancer are not
obvious. PARPi is generally well … It also could help in identifying cancer-related genes and …

[HTML][HTML] Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects

ZQ Han, LN Wen - World Journal of Gastrointestinal Oncology, 2023 - ncbi.nlm.nih.gov
… , G-quadruplex structures have obvious polymorphisms. X-ray … -quadruplex stability may
reduce replication initiation activity … G-quadruplexes of cancer-related genes in cancer cells and …

The decreased exclusion of nuclear eccDNA: From molecular and subcellular levels to human aging and age-related diseases

GH Qiu, X Zheng, M Fu, C Huang, X Yang - Ageing research reviews, 2021 - Elsevier
… on various activities such as DNA replication, transcription, cell cycle, … is critical to the integrity
and stability of the genome. … physical protection of the genome and central protein-coding …

Beyond the double-strand breaks: the role of DNA repair proteins in cancer stem-cell regulation

J Nathansen, F Meyer, L Müller, M Schmitz… - Cancers, 2021 - mdpi.com
genes cognitively often correlates with CFS instability. In addition, CFSs have a low density
of replication initiation events and are replicated … of a breast cancer-related mutant leads to …

Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response

J Mandal, P Mandal, TL Wang, IM Shih - Journal of biomedical science, 2022 - Springer
… a number of cancer related genes including PIK3IP1 [36], … exhibited significant replication
stress, replication fork instability, … adverse effects can become more apparent. A better dosing …

[PDF][PDF] The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export

A Olazabal-Herrero, B He, Y Kwon, AK Gupta, A Dutta… - Cell reports, 2024 - cell.com
replication fork protection. Defects in the FA pathway lead to R-loop accumulation, which
contributes to genomic instability… , R97Q, and W134C SRSF1 cancerrelated mutations furnishes …

[HTML][HTML] PARP inhibitor resistance in ovarian cancer: Underlying mechanisms and therapeutic approaches targeting the ATR/CHK1 pathway

Ł Biegała, A Gajek, A Marczak, A Rogalska - Biochimica et Biophysica Acta …, 2021 - Elsevier
… common cause of gynecologic cancer-related death in women … Interestingly, no impact on
PARPi sensitivity was evident in … functions at replication forks to maintain genome stability and …

[HTML][HTML] Evaluation of oxidative stress and genetic instability among residents near mobile phone base stations in Germany

S Gulati, W Mosgoeller, D Moldan, P Kosik… - Ecotoxicology and …, 2024 - Elsevier
… , and specific cancer related genetic markers, like MLL gene … A whole gene duplication is
represented by an additional site … The most noticeable correlation was among the different …

ECRG2/SPINK7 Tumor Suppressor as Modulator of DNA Damage Response

H Patel, MS Sheikh, Y Huang - International Journal of Molecular …, 2024 - mdpi.com
… mRNA stability and the expression of transcripts corresponding to many cancer-related
genes. … ECRG2 is also implicated in proper centrosome duplication during the interphase and …