The conserved role of RNA splicing factors in genome maintenance
AS Tam - 2020 - open.library.ubc.ca
… This work identifies distinct causes of genetic instability when … to be a protective effect of
introns on R-loop suppression in … R-loop mediated replication stress, and changes in gene …
introns on R-loop suppression in … R-loop mediated replication stress, and changes in gene …
[HTML][HTML] USP7 is a master regulator of genome stability
GJ Valles, I Bezsonova, R Woodgate… - Frontiers in Cell and …, 2020 - frontiersin.org
… evident role of USP7 in maintaining genome stability, the … ∼50 amino acid sequence with
a polyglutamine region, … the cell cycle, replication, mitosis and telomere stability. We will …
a polyglutamine region, … the cell cycle, replication, mitosis and telomere stability. We will …
[HTML][HTML] The role of alternative splicing in cancer: From oncogenesis to drug resistance
R Sciarrillo, A Wojtuszkiewicz, YG Assaraf… - Drug Resistance …, 2020 - Elsevier
… a broad spectrum of relevant genes involved in drug uptake/… of the plethora of cancer-related
splicing alterations. … of genes (introns) are removed and the coding sequences (exons…
splicing alterations. … of genes (introns) are removed and the coding sequences (exons…
3′ untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance
… Cancer-related genes have evolved specific genetic and … gene expression by influencing
mRNA location, stability, and … covariates, including gene expression, DNA replication time, …
mRNA location, stability, and … covariates, including gene expression, DNA replication time, …
[HTML][HTML] DNA damage in cancer development: special implications in viral oncogenesis
M Katerji, PJ Duerksen-Hughes - American Journal of Cancer …, 2021 - ncbi.nlm.nih.gov
… in carcinogenesis became particularly apparent when it was … replication, preventing genomic
instability upon replication … to overexpression of cellular cancer-related genes, such as …
instability upon replication … to overexpression of cellular cancer-related genes, such as …
[HTML][HTML] Cancer genes and cancer stem cells in tumorigenesis: Evolutionary deep homology and controversies
VF Niculescu - Genes & Diseases, 2022 - Elsevier
… I suggest that unstable early metazoans that carried the G + … to repair DNA replication and
polyploidization defects and … et al traces cancer-related polyploidy genes to a time when …
polyploidization defects and … et al traces cancer-related polyploidy genes to a time when …
[HTML][HTML] Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: Review of radiosensitivity assays
… and the first leading cause of cancer-related death in women … is limited to the full sequencing
of the genes. However, this … of tandem duplication [47] and RNA-DNA hybrid (R loop) …
of the genes. However, this … of tandem duplication [47] and RNA-DNA hybrid (R loop) …
Genome Instability Observed in Heterozygotic BRCA1 Mutation Mice
X Wu - 2022 - search.proquest.com
… We also observed that the genes affected by genome instability … and included breast-cancer-related
genes. We further observed … -like repetitive DNA sequence during replication and …
genes. We further observed … -like repetitive DNA sequence during replication and …
Molecular Genetics of Cancer
B Chuphal - Genetics Fundamentals Notes, 2022 - Springer
… replication or growth comes an inevitable hazard of genetic … Carcinoma often refers to cancer
related to body lining (internal … bring about genomic stability and chromosome integrity. At a …
related to body lining (internal … bring about genomic stability and chromosome integrity. At a …
[HTML][HTML] RNA-binding proteins as important regulators of long non-coding RNAs in cancer
… role in the deregulation of cancer-related lncRNAs. There are, … NEAT1 but no apparent
impact on the stability of MALAT1. … that is also involved in mitochondrial DNA replication [68,121]. …
impact on the stability of MALAT1. … that is also involved in mitochondrial DNA replication [68,121]. …