BRCA1 mutations in cancer: coordinating deficiencies in homologous recombination with tumorigenesis

JJ Krais, N Johnson - Cancer research, 2020 - AACR
… , or genome stability and protection from tumor development. … to breast and ovarian
cancerrelated mortality. The process of … the relationship between replication fork protection and …

DYNLL1 mis-splicing is associated with replicative genome instability in SF3B1 mutant cells

AS Tam, S Tsai, EYC Chang, V Mathew, A Shanks… - BioRXIV, 2021 - biorxiv.org
… while R-loop formation and associated replication stress may … Single-stranded DNA damage
was also evident in the … for 30 mins at room temperature protected from light. Lastly, cells …

[PDF][PDF] Role of DNA Repair in Genome Stability, Tumor Prevention, and Main Complications in Case of Repair Failure

MR Hayek, J Timmins - 2022 - videleaf.com
… ) or to errors during DNA replication. Some mutations are … ; this is particularly obvious in
case of genetic defects in the … most commonly occurring cancer-related DNA repair defects. …

[HTML][HTML] A Review of the Repair of DNA Double Strand Breaks in the Development of Oral Cancer

SS Prime, P Darski, KD Hunter, N Cirillo… - International journal of …, 2024 - mdpi.com
… accumulation of DSBs is due to replication stress, but later, current … To explain the apparent
paradox that cells remain vital … instability, but further work is required to determine whether …

[HTML][HTML] Epigenetic mechanisms and the hallmarks of cancer: An intimate affair

N Darwiche - American journal of cancer research, 2020 - ncbi.nlm.nih.gov
… the most to malignancy and cancer-related death. Invasion and … compaction and impact
gene regulation, DNA replication, DNA … in microsatellite repeat stability [190-192]. The BRAC1 …

[HTML][HTML] WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer

Q Zhou, X Chen, H He, S Peng, Y Zhang, J Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
… leading cause of male cancer-related death in the Western … However, the negative control
and CDK1 were no obvious … BIRC5 could protect chromosome stability independently from …

Variations in genomic regions encoding long non-coding RNA genes associated with increased prostate cancer risk

E Bozgeyik - Mutation Research/Reviews in Mutation Research, 2023 - Elsevier
… /clinical recurrence and prostate cancer-related mortality 4, 5. … unstable lncRNA (gene length,
25 kb; PCR target sequence … of treatment, it is obvious that the variations occurring at the …

[HTML][HTML] Identification of LncRNA prognostic signature associated with genomic instability in pancreatic adenocarcinoma

J Zhu, Q Huang, X Peng, C Luo, S Liu, Z Liu… - Frontiers in …, 2022 - frontiersin.org
… Conclusions: In conclusion, it was evident that the GILncSig … , which is ranked fourth for
cancer-related deaths in the United … telomere transcription, replication, and recombination, hence …

Transcriptional regulators of human oncoviruses: structural and functional implications for anticancer therapy

I Nečasová, M Stojaspal, E Motyčáková, T Brom… - NAR …, 2022 - academic.oup.com
… proteins to enable viral genome replication. As vTRs are unique … Despite the apparent
importance of vTRs in human health and … Moreover, Rex increases viral RNA stability during the …

Structural variation in cancer: role, prevalence, and mechanisms

MR Cosenza, B Rodriguez-Martin… - … and Human Genetics, 2022 - annualreviews.org
… oncogenic effects on cancer-related gene expression are … whole-genome duplication are
more genomically unstable and at … genetic loci, typically amplified oncogenes, which are visible