… two key populations of myeloid cells involved in pathology of … amino acid availability and
metabolism affects their function … Arginine metabolism is a key regulator of myeloid function, …

… myeloid cells. The role of L-arginine (L-arg) metabolism in the regulation of immune response
… co-stimulatory signals and release cytokines that shape T-cell responses. The same role is …

… [ 89, 90 ] In hypoxic conditions, macrophages sense low-oxygen stress, and this leads to
elevated expression of ARG1, [ 91 ] which mediates the L-arginine metabolism essential for the …

… metabolic profiles of intratumoral myeloid cells are rewired to adapt to the nutrition-limited
tumor microenvironment, and this shapes … Metabolism of the essential amino acid l-arginine by …

… Here, we review immune responses during Mtb infection and immune cell metabolism of two
key amino … In summary, following infection myeloid cells express IDO, thereby depleting the …

… population of immature myeloid cells that are characterized … of glycolytic enzymes and thus
shapes the fate of MDSCs. … of arginine into l-ornithine and urea by Arg1 leads to arginine …

… report RANKL cellular programming requires extracellular arginine. Systemic arginine
restriction … IL-4 induces myeloid cell multinucleation 34 , resulting in MGCs that are distinct from …

… , arginine is a key metabolite in vascular function and tone due to its role in the production of
nitric oxide (NO). Indeed, arginine is metabolized … for nutrients shape immunity and to what …

… by cancer and stromal cell communication that shapes the tumor … The first branch of arginine
metabolism is its conversion to NO … synthesis or immune activation in myeloid cells through …

… metabolism shape phenotypic outcomes in innate immune … Increased numbers of myeloid
cells and induction of TLRs and … of arginine metabolism, citrulline can be recycled to arginine …