[HTML][HTML] Bronchial epithelial cells on the front line to fight lung infection-causing Aspergillus fumigatus

J Bigot, L Guillot, J Guitard, M Ruffin, H Corvol… - Frontiers in …, 2020 - frontiersin.org
fumigatus conidia and hyphae and induces the release of pro-inflammatory molecules. …
interferon-β and interferon-γ-inducible protein-10, through TLR3 signaling. Interestingly, this …

Involvement of JNK signaling in Aspergillus fumigatus-induced inflammatory factors release in bronchial epithelial cells

X Cui, F Chen, J Zhao, D Li, M Hu, X Chen, Y Zhang… - Scientific Reports, 2023 - nature.com
… Mitogen-activated protein kinase (MAPK) signaling pathway played an important role in …
of cytokines induced by A. fumigatus conidia in human bronchial epithelial cells BEAS-2B were …

Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment

H Kushima, T Tsunoda, T Matsumoto, Y Kinoshita… - Microorganisms, 2021 - mdpi.com
Aspergillus-mediated signaling pathway in epithelial cells and … between AF conidia and
epithelial cells or fibroblasts in a … concentrations of AF293 conidia induce A549 apoptosis along …

… ) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling

A Dietschmann, S Schruefer, S Westermann, F Henkel… - Mbio, 2022 - Am Soc Microbiol
aspergillosis (ABPA). Here, we show that intranasal administration of live Aspergillus fumigatus
conidia causes fatal lung … It is also required as an adhesin to epithelial cells, very much in …

Characterisation of Aspergillus fumigatus Endocytic Trafficking within Airway Epithelial Cells Using High-Resolution Automated Quantitative Confocal Microscopy

N Ben-Ghazzi, S Moreno-Velásquez, C Seidel… - Journal of Fungi, 2021 - mdpi.com
Aspergillus fumigatus survival within airway epithelial cells has been impaired by the lack
of live-cellfumigatus spores taken up by airway epithelial cells, those contained within …

Aspergillus fumigatus drives tissue damage via iterative assaults upon mucosal integrity and immune homeostasis

UJ Okaa, M Bertuzzi, R Fortune-Grant… - Infection and …, 2023 - Am Soc Microbiol
… spores, the most prevalent worldwide cause of fungal respiratory disease. … We found that
airway epithelial cells respond in a distinctive and dynamic manner to A. fumigatus conidia, …

Novel Insights into Aspergillus fumigatus Pathogenesis and Host Response from State-of-the-Art Imaging of Host–Pathogen Interactions during Infection

SC Ortiz, K Pennington, DD Thomson, M Bertuzzi - Journal of Fungi, 2022 - mdpi.com
fumigatus conidial lung deposition in murine models of … fumigatus, both positively (by
inducing fungal cell wall changes … by bronchial epithelial cells, and uptake by alveolar epithelial

MDA5 is an essential sensor of a pathogen-associated molecular pattern associated with vitality that is necessary for host resistance against Aspergillus fumigatus

X Wang, AK Caffrey-Carr, K Liu, V Espinosa… - The Journal of …, 2020 - journals.aai.org
fumigatus conidia, airway epithelial cells and lung-resident macrophages comprise the first
line of defense against inhaled conidia. It is … signaling in the induction of IFNs after respiratory

MAVS expression in alveolar macrophages is essential for host resistance against Aspergillus fumigatus

X Wang, C Cunha, MS Grau, SJ Robertson… - The Journal of …, 2022 - journals.aai.org
… in the lung by histological analysis at 40 h after conidial … human bronchial epithelial cells was
sufficient for inducing IFN-β … domain–containing adapter inducing IFN-β) signaling, they did …

Increased fungal infection mortality induced by concurrent viral cellular manipulations

K Roe - Lung, 2023 - Springer
… monocyte phagocytosis of Aspergillus conidia, allowing their … of alveolar epithelial cells
(pneumocytes), and lung invasion … TRIF = TIR-domain-containing adapter-inducing interferon-β. …