[HTML][HTML] Bronchial epithelial cells on the front line to fight lung infection-causing Aspergillus fumigatus
… fumigatus conidia and hyphae and induces the release of pro-inflammatory molecules. …
interferon-β and interferon-γ-inducible protein-10, through TLR3 signaling. Interestingly, this …
interferon-β and interferon-γ-inducible protein-10, through TLR3 signaling. Interestingly, this …
Involvement of JNK signaling in Aspergillus fumigatus-induced inflammatory factors release in bronchial epithelial cells
X Cui, F Chen, J Zhao, D Li, M Hu, X Chen, Y Zhang… - Scientific Reports, 2023 - nature.com
… Mitogen-activated protein kinase (MAPK) signaling pathway played an important role in …
of cytokines induced by A. fumigatus conidia in human bronchial epithelial cells BEAS-2B were …
of cytokines induced by A. fumigatus conidia in human bronchial epithelial cells BEAS-2B were …
Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment
H Kushima, T Tsunoda, T Matsumoto, Y Kinoshita… - Microorganisms, 2021 - mdpi.com
… Aspergillus-mediated signaling pathway in epithelial cells and … between AF conidia and
epithelial cells or fibroblasts in a … concentrations of AF293 conidia induce A549 apoptosis along …
epithelial cells or fibroblasts in a … concentrations of AF293 conidia induce A549 apoptosis along …
… ) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling
A Dietschmann, S Schruefer, S Westermann, F Henkel… - Mbio, 2022 - Am Soc Microbiol
… aspergillosis (ABPA). Here, we show that intranasal administration of live Aspergillus fumigatus
conidia causes fatal lung … It is also required as an adhesin to epithelial cells, very much in …
conidia causes fatal lung … It is also required as an adhesin to epithelial cells, very much in …
Characterisation of Aspergillus fumigatus Endocytic Trafficking within Airway Epithelial Cells Using High-Resolution Automated Quantitative Confocal Microscopy
N Ben-Ghazzi, S Moreno-Velásquez, C Seidel… - Journal of Fungi, 2021 - mdpi.com
… Aspergillus fumigatus survival within airway epithelial cells has been impaired by the lack
of live-cell … fumigatus spores taken up by airway epithelial cells, those contained within …
of live-cell … fumigatus spores taken up by airway epithelial cells, those contained within …
Aspergillus fumigatus drives tissue damage via iterative assaults upon mucosal integrity and immune homeostasis
UJ Okaa, M Bertuzzi, R Fortune-Grant… - Infection and …, 2023 - Am Soc Microbiol
… spores, the most prevalent worldwide cause of fungal respiratory disease. … We found that
airway epithelial cells respond in a distinctive and dynamic manner to A. fumigatus conidia, …
airway epithelial cells respond in a distinctive and dynamic manner to A. fumigatus conidia, …
Novel Insights into Aspergillus fumigatus Pathogenesis and Host Response from State-of-the-Art Imaging of Host–Pathogen Interactions during Infection
… fumigatus conidial lung deposition in murine models of … fumigatus, both positively (by
inducing fungal cell wall changes … by bronchial epithelial cells, and uptake by alveolar epithelial …
inducing fungal cell wall changes … by bronchial epithelial cells, and uptake by alveolar epithelial …
MDA5 is an essential sensor of a pathogen-associated molecular pattern associated with vitality that is necessary for host resistance against Aspergillus fumigatus
X Wang, AK Caffrey-Carr, K Liu, V Espinosa… - The Journal of …, 2020 - journals.aai.org
… fumigatus conidia, airway epithelial cells and lung-resident macrophages comprise the first
line of defense against inhaled conidia. It is … signaling in the induction of IFNs after respiratory …
line of defense against inhaled conidia. It is … signaling in the induction of IFNs after respiratory …
MAVS expression in alveolar macrophages is essential for host resistance against Aspergillus fumigatus
… in the lung by histological analysis at 40 h after conidial … human bronchial epithelial cells was
sufficient for inducing IFN-β … domain–containing adapter inducing IFN-β) signaling, they did …
sufficient for inducing IFN-β … domain–containing adapter inducing IFN-β) signaling, they did …
Increased fungal infection mortality induced by concurrent viral cellular manipulations
K Roe - Lung, 2023 - Springer
… monocyte phagocytosis of Aspergillus conidia, allowing their … of alveolar epithelial cells
(pneumocytes), and lung invasion … TRIF = TIR-domain-containing adapter-inducing interferon-β. …
(pneumocytes), and lung invasion … TRIF = TIR-domain-containing adapter-inducing interferon-β. …