Pathways in uremic cardiomyopathy–the intracellular orchestrator PGC-1α in cell culture and in a mouse model of uremia

TJ Bergmann - 2022 - opus.bibliothek.uni-wuerzburg.de
… Erk in urea-treated h9c2 cells. Western blot analysis of h9c2 cells that were treated with
glucose, … capacity indicates how close a cell is operating to its bioenergetic limit. After adding the …

Cardiac Troponin I Directly Binds and Inhibits Mitochondrial ATP Synthase: a Noncanonical Role in the Post-Ischemic Heart

A Elezaby, AJ Lin, V Vijayan, S Pokhrel, LRG Bechara… - bioRxiv, 2023 - biorxiv.org
… mitochondrial function, bioenergetics and redox balance in … To visualize cTnI localization,
we transfected H9c2 cardiac … We therefore assessed the effect of P888 treatment on the …

BDNF mimetic 7, 8-dihydroxyflavone rescues rotenone-induced cytotoxicity in cardiomyocytes by ameliorating mitochondrial dysfunction

PZ Hang, FQ Ge, MR Zhang, QH Li, HQ Yu… - Free Radical Biology …, 2023 - Elsevier
… Mitochondrial dysfunction, which is characterized by bioenergetic impairment and … analysis
of phosphorylation STAT3 at Tyr705 site in the cytoplasmic and nuclear fractions of H9c2 cells

Cell-permeable succinate rescues mitochondrial respiration in cellular models of amiodarone toxicity

AM Bețiu, I Chamkha, E Gustafsson, E Meijer… - International Journal of …, 2021 - mdpi.com
… -linked (Figure 2G) OXPHOS, we assessed the effects of amiodarone and rotenone (as the
positive control for complex I-inhibition) on mitochondrial respiration and cellular ATP levels. …

Carvedilol Phenocopies PGC-1α Overexpression to Alleviate Oxidative Stress, Mitochondrial Dysfunction and Prevent Doxorubicin-Induced Toxicity in Human iPSC …

N Uche, Q Dai, S Lai, K Kolander, M Thao, E Schibly… - Antioxidants, 2023 - mdpi.com
… To assess cell protection, we first incubated H9c2 cells and … before performing an assessment
of the cell viability using the … effects of carvedilol are primarily to preserve bioenergetic

Protective effects of β-caryophyllene on mitochondrial damage and cardiac hypertrophy pathways in isoproterenol-induced myocardial infarcted rats

A Yovas, SP Stanely, SMP Ponnian - European Journal of Pharmacology, 2023 - Elsevier
assessed the effects of β-caryophyllene on these enzymes and Ca 2+ . The hypoxia in
tissues and surplus free radicals production by isoproterenol reduces the activities of TCA cycle …

Identification of small molecules inhibiting cardiomyocyte necrosis and apoptosis by autophagy induction and metabolism reprogramming

D Liu, F Peyre, YA Loissell-Baltazar, D Courilleau… - Cells, 2022 - mdpi.com
… The percentage of viable cells was evaluated by methylene blue staining [10]. After … to
measure cellular bioenergetic function. H9c2 cells were seeded at 20,000 cells per well in XFe96 …

MMP9 inhibition increases autophagic flux in chronic heart failure

SS Nandi, K Katsurada, NM Sharma… - American Journal …, 2020 - journals.physiology.org
… In this study, by assessing left … H9c2 cells was validated by Western immunoblot and in-gel
gelatin zymography techniques. We represent these cells as knockdown MMP9 +/− H9c2

H2S-mediated blockage of protein acetylation and oxidative stress attenuates lipid overload-induced cardiac senescence

R Yu, Y Wang, J Zhu, G Yang - Archives of Physiology and …, 2024 - Taylor & Francis
… The developed colour of methylene blue was quantified at … the effect of H 2 S on cardiac
cell senescence, H9C2 cells … change, we then assessed the global acetylated lysine level …

The Role of Mitochondrial Bioenergetics in Cell Death Mechanisms in the Heart: Ferroptotic Pathways

XR Chapa-Dubocq - 2021 - search.proquest.com
… chemically induced ferroptosis in H9c2 cells. FIGURE 5.9. … assessing the role of ferroptosis
in cardiac dysfunction, we will expand our knowledge on the impact of this relatively new cell