Advancements in Stimulus-Responsive, H2S-Donating Motifs: Design, Synthesis, and Biological Applications

Q Hu - 2023 - search.proquest.com
… in H9c2 cardiomyoblasts while maintaining its antitumor effects … at assessing its effects on
mitochondrial bioenergetics, which … our methylene blue assay (Figure 3.3). However, unlike the …

[HTML][HTML] Functional annotation map of natural compounds in traditional Chinese medicines library: TCMs with myocardial protection as a case

X Xing, M Sun, Z Guo, Y Zhao, Y Cai, P Zhou… - … Pharmaceutica Sinica B, 2023 - Elsevier
… Targeted analysis was performed to screen out the effects of Fractions on mitochondria.
Therefore, mitochondria in H9c2 cells or NRVMs were isolated and purified by mitochondrial …

[HTML][HTML] Insulin-like growth factor II prevents MPP+ and glucocorticoid mitochondrial-oxidative and neuronal damage in dopaminergic neurons

S Claros, P Cabrera, N Valverde, SY Romero-Zerbo… - Antioxidants, 2021 - mdpi.com
… The bioenergetic assessment is shown in Figure 4. Thus, the … of the cellular bioenergetic
parameters: basal O 2 consumption, maximal and ATP-linked respirations, and the bioenergetic

Elucidating a thermoresponsive multimodal photo-chemotherapeutic nanodelivery vehicle to overcome the barriers of doxorubicin therapy

JB Nair, MM Joseph, JS Arya, P Sreedevi… - … Applied Materials & …, 2020 - ACS Publications
… , both HGNP and HGNPSC 4 retained more than 80% cell viability over a wide range of …
normal cells. Next, the cytotoxicity profile of TTNDV was assessed in HeLa, A549, and H9c2 cells

[HTML][HTML] Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy

J Hu, T Liu, F Fu, Z Cui, Q Lai, Y Zhang, B Yu… - Journal of translational …, 2022 - Springer
… led to impaired mitochondrial bioenergetics and defective trans-… Damaged mitochondria
were assessed by calculating the … the culture supernatants of H9c2 cells were used to measure …

3-MST/H2S protects cerebral endothelial cells against 2 OGD/R-induced injury via mitoprotection and inhibition of the 3 RhoA/ROCK pathway 4

F Zhang, S Chen, JY Wen, ZW Chen - 2020 - journals.physiology.org
… on the formation of methylene blue as previously described 209 with … In H9c2 cells after
ischemia-reperfusion injury, the ROCK … stress suppresses the cellular bioenergetic effect of the 3-…

Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity …

KN Papanicolaou, D Ashok, T Liu, TM Bauer… - … of molecular and cellular …, 2020 - Elsevier
… Patch-clamp analysis in H9C2 mitoplasts overexpressing … recorded along with the other two
bioenergetic parameters. (C) Aliquots … By methylene blue diffusion, we observed no physical …

KATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury

LN Maslov, SV Popov, NV Naryzhnaya… - Fundamental & …, 2023 - Wiley Online Library
H9c2 cells were subjected to anoxia/reoxygenation [126]. This impact induced apoptosis
of H9c2 cells… Diazoxide inhibited creatine kinase and LDH release from H9c2 cells, …

Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice

S Chang, J Tat, SP China, H Kalyanaraman… - PNAS …, 2022 - academic.oup.com
… Next, we tested the effect of cobinamide and the comparator drugs on hydrogen peroxide-induced
oxidative stress. We treated H9c2 cells with H 2 O 2 and assessed phosphorylation/…

Pharmacological modulation of calcium in selective cardiovascular disorders through store operated calcium entry inhibitors

HH Savsani - 2021 - search.proquest.com
… Drugs were evaluated on H9c2 cell through cytoprotective assay, Intra cellular ROS and …
by western blot analysis. For the safety concern, drugs were evaluated on H9c2 cell and …