Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study

DB Rosoff, G Davey Smith, N Mehta, TK Clarke… - PLoS …, 2020 - journals.plos.org
… , P value = 0.008), and peripheral artery disease (PAD) (OR = 2.35, 95… summary-level MR
to investigate a potentially nonlinear relationship between alcohol consumption and CVD risk

Alcohol consumption and cardiovascular disease: a Mendelian randomization study

SC Larsson, S Burgess, AM Mason… - Circulation: Genomic …, 2020 - Am Heart Assoc
… This study provides evidence of a causal relationship between higher alcohol … , the association
between alcohol consumption and CVD other than stroke and coronary heart disease has …

Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies

IAT van de Luitgaarden, S van Oort, EJ Bouman… - European journal of …, 2022 - Springer
Mendelian randomization (MR) is an established method to … on the association between
alcohol consumption and cardiometabolic diseases, all-cause mortality and cardiovascular risk

Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study

J Lankester, D Zanetti, E Ingelsson, TL Assimes - PLoS One, 2021 - journals.plos.org
… In this study, we determine the causal relationship between alcohol and cardiovascular risk
factors and disease in the UK Biobank by performing an instrumental variable analysis using …

Association of habitual alcohol intake with risk of cardiovascular disease

KJ Biddinger, CA Emdin, ME Haas, M Wang… - JAMA network …, 2022 - jamanetwork.com
… Using fractional polynomial nonlinear mendelian randomization analyses with Alcohol
Use … polynomial nonlinear mendelian randomization analyses with Alcohol Use Disorder–…

Genetic instrumental variable analysis: time to call mendelian randomization what it is. The example of alcohol and cardiovascular disease

KJ Mukamal, MJ Stampfer, EB Rimm - European journal of epidemiology, 2020 - Springer
… In this review, we examine two separate dietary examples—the associations of alcohol and
folate consumption with cardiovascular disease—to illustrate several of the challenges with …

Association of cardiovascular risk factors and lifestyle behaviors with hypertension: a mendelian randomization study

S van Oort, JWJ Beulens, AJ van Ballegooijen… - …, 2020 - Am Heart Assoc
… genetic correlation between the different lipid traits, we used multivariable MR analyses to
adjust for the genetic correlation … Fifth, we explored the role of BMI in the association between

Mendelian randomization for cardiovascular diseases: principles and applications

SC Larsson, AS Butterworth… - European heart journal, 2023 - academic.oup.com
… These discoveries have enabled the Mendelian randomization (MR) design, which uses …
reduce confounding in genetic associations. Mendelian randomization analyses make a set of …

Using Mendelian randomization to evaluate the effects of alcohol consumption on the risk of coronary heart disease

RC Ellison, M Grønbæk, E Skovenborg - Drugs and Alcohol Today, 2021 - emerald.com
… This paper aims to evaluate the use of Mendelian randomization (MR) analyses for
judging the effects of alcohol consumption on the risk of coronary heart disease (CHD). …

Alcohol consumption and subclinical and clinical coronary heart disease: a Mendelian randomization analysis

T Hisamatsu, K Miura, Y Tabara… - European Journal of …, 2022 - academic.oup.com
drinking alcohol in response to underlying health conditions. However, our findings based on
Mendelian randomization analysis … higher alcohol intake in men with a higher CAC burden. …