OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study

KWD Ho, MR Wallace, R Staud… - The pharmacogenomics …, 2020 - nature.com
… Notably, there is tremendous interindividual variation in response to opioid analgesia. For …
these genotypes are associated with opioid response in our study. Due to the association with …

[PDF][PDF] The effect of genetic variation on the sensitivity to opioid analgesics in patients with postoperative pain: an updated meta-analysis

L Zhi-Xue, F Ye, L Wen-Yao, B Yan-Ping… - Pain …, 2023 - painphysicianjournal.com
correlation with CYP3A4 SNPs. In our meta-analysis, we failed to observe a significant
association between postoperative painassociated with OPRM1 gene polymorphism genotype

Pharmacogenomics in pain management: a review of relevant gene-drug associations and clinical considerations

E Brandl, Z Halford, MD Clark… - Annals of …, 2021 - journals.sagepub.com
… Genetic variability in COMT genotypes has been found to be associated with pain … of
interest, particularly in the context of opioid analgesic responsiveness. There are several genetic …

Genetic factors associated with pain severity, daily opioid dose requirement, and pain response among advanced cancer patients receiving supportive care

S Yennurajalingam, A Astolfi, V Indio, M Beccaro… - Journal of pain and …, 2021 - Elsevier
… to pain severity, opioid daily dose, and pain response were hampered by the limitations of
genotyping … have significant variability in cancer pain severity, daily opioid requirement, and …

The pharmacogenetics of opioid treatment for pain management

A Singh, C Zai, AG Mohiuddin… - Journal of …, 2020 - journals.sagepub.com
… into the interindividual variability in pain sensitivity; multiple … the modulation of pain, enhance
opioid analgesia and contribute … Genotyping tests identify specific sites in the genome that …

The association between selected genetic variants and individual differences in experimental pain

MU Lie, B Winsvold, J Gjerstad, D Matre… - … Journal of Pain, 2021 - degruyter.com
… Sample size calculations showed that with a two-sided significance level of 5 and 80%
power, 228 subjects were needed to detect a 10% difference in pain scores between genotypes

Genetics and opioids: towards more appropriate prescription in cancer pain

D Bugada, LF Lorini, R Fumagalli, M Allegri - Cancers, 2020 - mdpi.com
variation in opioid response; starting from the basics of … [34], with no association between
genotype and the serum … a patient less sensitive to opioid analgesic effects, and more …

Pharmacogenomics of pain management: the impact of specific biological polymorphisms on drugs and metabolism

EM Cornett, MA Carroll Turpin, A Pinner… - Current oncology …, 2020 - Springer
… partly explain the variation in individual differences in pain. Just … for metabolizing many opioid
analgesics. These variances result … opioid-related side effects were also 3435TT genotype

… and genotypic variations of drug metabolising enzymes and transporters in chronic pain patients facing adverse drug reactions or non-response to analgesics: A …

V Rollason, C Lloret-Linares, KI Lorenzini… - Journal of personalized …, 2020 - mdpi.com
… This study shows that the genotypic and phenotypic approach is … , and can be part of the
evaluation of chronic pain patients. … variability in response to psychotropic drugs is related to a …

Identification of sex-specific genetic associations in response to opioid analgesics in a White, non-Hispanic cohort from Southeast Minnesota

GS Lopes, JL Lopes, SJ Bielinski, SM Armasu… - The …, 2022 - nature.com
variability in pain treatments. We investigated sex-specific associations between genetic
variation and opioid … on- and off-capture genotype calls. Population structure was evaluated via …