OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study
KWD Ho, MR Wallace, R Staud… - The pharmacogenomics …, 2020 - nature.com
… Notably, there is tremendous interindividual variation in response to opioid analgesia. For …
these genotypes are associated with opioid response in our study. Due to the association with …
these genotypes are associated with opioid response in our study. Due to the association with …
[PDF][PDF] The effect of genetic variation on the sensitivity to opioid analgesics in patients with postoperative pain: an updated meta-analysis
L Zhi-Xue, F Ye, L Wen-Yao, B Yan-Ping… - Pain …, 2023 - painphysicianjournal.com
… correlation with CYP3A4 SNPs. In our meta-analysis, we failed to observe a significant
association between postoperative pain … associated with OPRM1 gene polymorphism genotype …
association between postoperative pain … associated with OPRM1 gene polymorphism genotype …
Pharmacogenomics in pain management: a review of relevant gene-drug associations and clinical considerations
E Brandl, Z Halford, MD Clark… - Annals of …, 2021 - journals.sagepub.com
… Genetic variability in COMT genotypes has been found to be associated with pain … of
interest, particularly in the context of opioid analgesic responsiveness. There are several genetic …
interest, particularly in the context of opioid analgesic responsiveness. There are several genetic …
Genetic factors associated with pain severity, daily opioid dose requirement, and pain response among advanced cancer patients receiving supportive care
… to pain severity, opioid daily dose, and pain response were hampered by the limitations of
genotyping … have significant variability in cancer pain severity, daily opioid requirement, and …
genotyping … have significant variability in cancer pain severity, daily opioid requirement, and …
The pharmacogenetics of opioid treatment for pain management
A Singh, C Zai, AG Mohiuddin… - Journal of …, 2020 - journals.sagepub.com
… into the interindividual variability in pain sensitivity; multiple … the modulation of pain, enhance
opioid analgesia and contribute … Genotyping tests identify specific sites in the genome that …
opioid analgesia and contribute … Genotyping tests identify specific sites in the genome that …
The association between selected genetic variants and individual differences in experimental pain
… Sample size calculations showed that with a two-sided significance level of 5 and 80%
power, 228 subjects were needed to detect a 10% difference in pain scores between genotypes …
power, 228 subjects were needed to detect a 10% difference in pain scores between genotypes …
Genetics and opioids: towards more appropriate prescription in cancer pain
… variation in opioid response; starting from the basics of … [34], with no association between
genotype and the serum … a patient less sensitive to opioid analgesic effects, and more …
genotype and the serum … a patient less sensitive to opioid analgesic effects, and more …
Pharmacogenomics of pain management: the impact of specific biological polymorphisms on drugs and metabolism
EM Cornett, MA Carroll Turpin, A Pinner… - Current oncology …, 2020 - Springer
… partly explain the variation in individual differences in pain. Just … for metabolizing many opioid
analgesics. These variances result … opioid-related side effects were also 3435TT genotype …
analgesics. These variances result … opioid-related side effects were also 3435TT genotype …
… and genotypic variations of drug metabolising enzymes and transporters in chronic pain patients facing adverse drug reactions or non-response to analgesics: A …
V Rollason, C Lloret-Linares, KI Lorenzini… - Journal of personalized …, 2020 - mdpi.com
… This study shows that the genotypic and phenotypic approach is … , and can be part of the
evaluation of chronic pain patients. … variability in response to psychotropic drugs is related to a …
evaluation of chronic pain patients. … variability in response to psychotropic drugs is related to a …
Identification of sex-specific genetic associations in response to opioid analgesics in a White, non-Hispanic cohort from Southeast Minnesota
GS Lopes, JL Lopes, SJ Bielinski, SM Armasu… - The …, 2022 - nature.com
… variability in pain treatments. We investigated sex-specific associations between genetic
variation and opioid … on- and off-capture genotype calls. Population structure was evaluated via …
variation and opioid … on- and off-capture genotype calls. Population structure was evaluated via …