Importance The comparative effectiveness of rivaroxaban and apixaban, the most frequently
prescribed oral anticoagulants for ischemic stroke prevention in patients with atrial
fibrillation, is uncertain. Objective To compare major ischemic and hemorrhagic outcomes in
patients with atrial fibrillation treated with rivaroxaban or apixaban. Design, Setting, and
Participants Retrospective cohort study using computerized enrollment and claims files for
US Medicare beneficiaries 65 years or older. Between January 1, 2013, and November 30 …