… Additionally, small RNA molecules can modulate ATM … ATM mutations. Furthermore, the
design and interpretation of clinical studies assessing TOP1 inhibitors, PARPi (Poly-ADP ribose …

… The role of ATM signaling in the DDR has been widely … of its cousins, poly-ADP–ribose
polymerase (PARP) and ataxia … meant to identify novel compounds with radiosensitizing …

… -resistance, and modulate the immune microenvironment in … exist between the ATM and ATR
signaling pathways, these … evaluated AZD6738 with the poly-ADP ribose polymerase (PARP…

… The recent success of Poly (ADP-ribose) polymerase (PARP) … The in-depth roles of ATM
and ATR signalling pathways in … Conversely, another potential approach to modulate ATM …

… the regulatory role of ATM in modulating macropinocytosis, a … a repair complex and transfers
ADP-ribose to target proteins to … transmitting them to downstream signaling pathways (71). …

… Notably, it was suggested that ATM also phosphorylates and modulates the activity of key …
wide epigenetic changes in AT have provided novel advances in our understanding of how AT …

… with an increasing number of novel ATR inhibitors are assessed … 2.5, we have summarized
the ATM signaling network. … DNA break caused either through poly(ADP-ribose) polymerase (…

… ATM signaling pathways contain many downstream targets that … ATM modulates mitochondrial
function through nuclear … Poly (ADP-ribose) polymerases (PARPs) are key enzymes in the …

… -mitochondrial axis is modulated by ATM activity [59]. Loss of … event is the binding of
poly(ADP-ribose)polymerase I (PARP1) to … other signaling pathways together with ATM inhibitors …

… We recently reported that lymphoma cells adjust their metabolic demand by modulating …
a novel mouse lymphoma model of AT with an N-terminal mutation in ATM showed that ATM is …