[HTML][HTML] Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment

K Seaman, Y Sun, L You - Med-X, 2023 - Springer
… 3D tissue models as in vitro drug screening tools for novel anti-… tumour on a chip model by
using tri-culture spheroids … ablation and PDAC invasion in 2D patterned co-cultures and in …

Patient‐Derived Organoids as Therapy Screening Platforms in Cancer Patients

D Khorsandi, JW Yang, S Foster… - Advanced …, 2024 - Wiley Online Library
… The brain tumor PDOs (neurospheres) were evaluated for … U-251 MG cell spheroids. The
study further expanded its … 1), a platform of PDO-autologous T cell co-cultures was used for drug …

Tumor Organoids: The Era of Personalized Medicine

NV Rassomakhina, AY Ryazanova, AR Likhov… - Biochemistry …, 2024 - Springer
… 3D tumor models obtained by co-culturing autologous tumor … ) pathway promotes cancer cell
invasion and metastasis via the … spheroids and cells from a 2D culture differed: the spheroid-…

[HTML][HTML] The role of organoids in cancer research

Z Fang, P Li, F Du, L Shang, L Li - Experimental Hematology & Oncology, 2023 - Springer
… differentiated to generate isolated spheroids. In June 2022, a … organoids or to add exogenous
immune cells (autologous or … In conclusion, brain tumour organoids provide a platform for …

[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis

N Del Piccolo, VS Shirure, Y Bi… - Advanced drug delivery …, 2021 - Elsevier
… Future work should focus on the development of autologous … monolayer in 2D cultures and
a spheroid in 3D culture. These … remodeled ECM promotes tumor invasion and metastasis. In …

[HTML][HTML] Glioblastoma Vasculature: From its Critical Role in Tumor Survival to Relevant in Vitro Modelling

C Pacheco, C Martins, J Monteiro, F Baltazar… - Frontiers in Drug …, 2022 - frontiersin.org
… , aggressive and lethal primary brain tumor in adults. According … reported GBM spheroids
comprise only one human or one … of stromal cells, and even autologous stromal cells, might be …

Patient‐derived cancer organoids for drug screening: basic technology and clinical application

X Ren, W Chen, Q Yang, X Li… - … of Gastroenterology and …, 2022 - Wiley Online Library
… colorectal, liver, stomach, pancreatic and brain tumors. Some … as tumor cell migration and
invasion, tumor heterogeneity, … are isolated from autologous peripheral blood or tumor and co-…

[PDF][PDF] Evaluation of comprehensive gene expression and NK cell-mediated killing in glioblastoma cell line-derived spheroids. Cancers 2021; 13 (19)

T Morimoto, T Nakazawa, R Matsuda, F Nishimura… - 2021 - researchgate.net
… ) is the most aggressive primary malignant brain tumor in adults. … NK cells expanded from
our specific culture conditions on a … supplemented with 5% autologous plasma and 3000 IU/mL …

[HTML][HTML] Patient-derived organoids in precision medicine: drug screening, organoid-on-a-chip and living organoid biobank

Z Zhou, L Cong, X Cong - Frontiers in oncology, 2021 - frontiersin.org
… profound effects on tumor cell growth, invasion ability, and … autologous peripheral blood
lymphocytes generates tumor-… profiles of 3D cancer spheroids are different from 2D cultures, …

[HTML][HTML] Trends and challenges in modeling glioma using 3D human brain organoids

A Mariappan, G Goranci-Buzhala… - Cell Death & …, 2021 - nature.com
… Glioma is an aggressive form of brain cancer characterized by poor … 3D culture systems to
study glioma invasion biology. … invasion assays between homologous and autologous assays …