[HTML][HTML] Current concepts in tumour-derived organoids

RJ Porter, GI Murray, MH McLean - British journal of cancer, 2020 - nature.com
… Hence, although spheroid culture is a useful 3D culture … This approach has provided
invaluable insights into cancer invasionAutologous co-culture of tumour organoids derived from …

[HTML][HTML] 3D cancer models: Depicting cellular crosstalk within the tumour microenvironment

T Franchi-Mendes, R Eduardo, G Domenici, C Brito - Cancers, 2021 - mdpi.com
… The role of the TME in tumorigenesis, tumour progression, invasion and … spheroids are
related to the simplified architecture and ECM; autologous ECM is built up along culture

[HTML][HTML] Preclinical models for neuroblastoma: Advances and challenges

JC Nolan, T Frawley, J Tighe, H Soh, C Curtin… - Cancer letters, 2020 - Elsevier
Spheroid models offer many advantages over 2D cultures and … junctions by cells growing
in spheroids, reveals the enhanced … -mesenchymal structures, tumour invasion, and vascular …

[HTML][HTML] Generation of glioblastoma in mice engrafted with human cytomegalovirus-infected astrocytes

J Guyon, S Haidar Ahmad, R El Baba… - Cancer Gene …, 2024 - nature.com
… of CEGBCs, and spheroid formation as well as invasion in 3D cultures. In agreement with …
into the diagnostic framework, classifying and grading brain tumors [2]. Thus, the presence …

[HTML][HTML] Opportunities and challenges to engineer 3D models of tumor-adaptive immune interactions

RM Visalakshan, MK Lowrey, MGC Sousa… - Frontiers in …, 2023 - frontiersin.org
… The use of 3D cell cultures can help recreate complex … 3D models can be done with autologous
cells, however populations … , cancer cells migrated from the central spheroid and invaded

[HTML][HTML] Give Them Vasculature and Immune Cells: How to Fill the Gap of Organoids

S Yip, N Wang, R Sugimura - Cells Tissues Organs, 2023 - karger.com
… for 3D culture models, shifting from simple 3D cell aggregates … Not only did the vessels
invade the brain organoids and form … with autologous CTLs and mouse or human gastric cancer

[HTML][HTML] Microfluidic technologies for immunotherapy studies on solid tumours

K Paterson, S Zanivan, R Glasspool, SB Coffelt… - Lab on a Chip, 2021 - pubs.rsc.org
… , such as spheroids, organoids 10 and tumour tissue slices. … in treating melanoma and brain
cancer. With regard to solid … new programmes for developing autologous and allogeneic cell …

[HTML][HTML] Newly developed 3D in vitro models to study tumor–immune interaction

P Mu, S Zhou, T Lv, F Xia, L Shen, J Wan… - … & Clinical Cancer …, 2023 - Springer
… Thus the tumor spheroid and immune cell co-culture model is a usable tool to study tumor-…
Therefore, macrophages may play a role in the invasion and metastasis of colon cancer [34]…

[HTML][HTML] Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies

C Bouquerel, A Dubrova, I Hofer, DTT Phan… - Lab on a Chip, 2023 - pubs.rsc.org
… stroma and pharmacokinetics as well as an intact autologous … Organoids and spheroid
cultures are also associated with … CAF-S4 promote cancer invasion and metastasis but with …

Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy

J Mei, X Liu, HX Tian, Y Chen, Y Cao… - Clinical and …, 2024 - Wiley Online Library
… The cell co-culture models, 10 material-assistant 3D cell culture models 11 and cancer
For instance, patient-derived CD8 + T cells and autologous gastric cancer cells were co-cultured …