… regulator of autophagy and lysosome function, can be regulated by … adaptive responses of
T cells to local environmental cues. … and functional integrity of Treg cells (31, 32). The defect of …

… -lymphoid sites enable them to recognize the metabolic cues and adapt their intracellular
metabolism and anti-inflammatory function at the paracrine and systemic levels. As privileged …

… , are closely interconnected with dynamic changes in cellular integrity and metabolism.
Therefore, … (A) The difference in regulatory T cell (Treg) differentiation between normal CD4 + …

… autophagy activation to sustain T reg cell metabolic programming and functional integrity. …
In our study, we showed that T reg cell–derived ZFP91 strengthened autophagy initiation to …

… ) or regulatory T cells (Tregs) is accompanied by the … , autophagy is important to maintain
the functional integrity of … Therefore, autophagy couples environmental cues and metabolic …

… -bet and CXCR3 in response to TCR signaling rather than environmental cues [73]. However,
in this study, the Tregs were stable, maintained their DNA-hypomethylation and did not …

… Regulatory T cells (Tregs) are vital for the maintenance of immune homeostasis, while their
… network integrity and activity is indispensable for immune cell homeostasis and function. …

… Autophagy and lysosomal function regulate Treg cell … Specifically, Treg cell-specific deletion
of the autophagy gene … that, metabolic cues determine the functional properties of Treg cells. …

… In effector T cells, autophagic programs are involved in mediating T cell immune responses
… Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues …

… ubiquitin-like coupling cascades, including autophagy-related 5 (… , autophagy in tumor cells
impairs T cell survival and function … acid via pressure-activated signals. These increased the …