Chemiexcitation and melanin in photoreceptor disc turnover and prevention of macular degeneration

Y Lyu, AV Tschulakow, K Wang… - Proceedings of the …, 2023 - National Acad Sciences
… by excited states such as formed by melanin chemiexcitation initiated by the combination
of … the cDNA for tyrosinase, the rate-limiting enzyme in the melanin synthesis pathway, is …

Melanin-binding colorants: Updating molecular modeling, staining and labeling mechanisms, and biomedical perspectives

JC Stockert, J Espada, A Blázquez-Castro - Colorants, 2022 - mdpi.com
… of spiral melanin units could be formed by aggregation of … found in classical tissue
histochemistry give metachromatic reactions, … ), whole body autoradiography has shown labeling …

Melanogenesis Is Directly Affected by Metabolites of Melatonin in Human Melanoma Cells

JKS Möller, K Linowiecka, M Gagat… - International journal of …, 2023 - mdpi.com
… subjected compounds on tyrosinase activity using amelanotic … of decreased TYR activity
and melanin synthesis. In parallel, … level is dependent on the formation of melanosomes, which …

Melanosomes degrade lipofuscin and precursors that are derived from photoreceptor membrane turnover in the retinal pigment epithelium—an explanation for the …

Y Lyu, AV Tschulakow, U Schraermeyer - BioRxiv, 2022 - biorxiv.org
… However, transfection with tyrosinase led to a reduction in the … from all mice were enucleated
and prepared for histology. … show that melanin is associated with TLMs and lipofuscin. …

Investigation of the role of melanosomes and radicals in photoreceptor disc clearance by the retinal pigment epithelium

Y Lyu - 2023 - tobias-lib.ub.uni-tuebingen.de
Tyrosinase-induced newly formed melanosomes show NIR-… with tyrosinase cDNA induces
RPE melanosome formation and … Tyrosinase is the rate-limiting enzyme in melanin synthesis. …

Neuromelanin modulates heterocyclic aromatic amine-induced dopaminergic neurotoxicity

V Lawana, SY Um, JC Rochet, RJ Turesky… - Toxicological …, 2020 - academic.oup.com
… We characterized melanin from Sepia officinalis and … in the presence of tyrosinase enzyme
can lead to neuromelanin … cells at 48 h, demonstrating the formation of melanin in TYR SH-…

The skin-color is associated with its physiological state: A case study on a colorful variety, hybrid grouper (Epinephelus fuscoguttatus× Epinephelus lanceolatus)

K Zhou, K Zhang, X Fan, W Zhang, Y Liang, X Wen… - Aquaculture, 2022 - Elsevier
… China) and autoradiography. Chemiluminescent detection … melanin production pathway
affects the fish skin color variation. In the tyrosine metabolic pathway, the expression and activity

[PDF][PDF] Biomedical overview of melanin. 2. Updating molecular modeling, synthesis mechanism, and supramolecular properties regarding melanoma therapy

JC Stockert, A Blázquez-Castro - Biocell, 2022 - cdn.techscience.cn
… In human melanosomes, melanin appears as formed by a … of melanin is limited to
Stages III–IV, but tyrosinase activity is … be histochemically detected by tyrosinase assays (Angeletti …

Human equivalent doses of l-DOPA rescues retinal morphology and visual function in a murine model of albinism

A Sanchez-Bretano, E Keeling, JA Scott, SA Lynn… - Scientific Reports, 2023 - nature.com
… to l-DOPA, and l-DOPA to melanin in pigmented cells including … Data obtained from the
OCT, ERG, OptoMotry and histology … The lack of tyrosinase activity in OCA1 causes a lack of l-…

Inhibitory actions of melanin‐concentrating hormone in the lateral septum

MA Payant, CD Spencer, NKK Ly… - The Journal of …, 2023 - Wiley Online Library
… A), which formed our focus region for identifying MCH-responsive LS cells and defining
the mechanisms of MCH action. … Based on our histological preparations (Fig. 7…