[HTML][HTML] Novel neuroprotective therapy with NeuroHeal by autophagy induction for damaged neonatal motoneurons

D Romeo-Guitart, C Marcos-DeJuana… - Theranostics, 2020 - ncbi.nlm.nih.gov
… nerve axotomy in rat pups, that induces retrograde apoptotic death of motoneurons. … , a
new neuroprotective agent for adult axotomized spinal motoneurons (MNs), using a top-…

Restoration of injured motoneurons reduces microglial proliferation in the adult rat facial nucleus

T Ishijima, K Nakajima - Journal of Neuropathology & …, 2024 - academic.oup.com
Axotomy of rat facial motoneurons causes a reduction in func… Sal) on the axotomized
motoneurons, we axotomized both the left … fashion by spinal cord motoneurons in neonatal rats …

Induction of Nitric Oxide and Its Role in Facial Nerve Regeneration According to the Method of Facial Nerve Injury

YJ Oh, DK Yon, YS Choi, J Lee, JH Yeo, SS Kim… - Antioxidants, 2024 - mdpi.com
… (ricin) NADPH-d histochemistry NOS NADPH-d activity is … showed that reactive astrocytes
around axotomized motoneurons … for iNOS in neonatal (3-day-old) rats, but negative in adult (2-…

Nitric oxide controls excitatory/inhibitory balance in the hypoglossal nucleus during early postnatal development

F Portillo, B Moreno-López - Brain Structure and Function, 2020 - Springer
NO at neonatal stage induces loss of both excitatory and inhibitory boutons even though
findings: (1) it is well known that adult motor neurons do not express NOS (Moreno-López 2010)…

Nitric oxide controls excitatory/inhibitory balance in the hypoglossal nucleus during early postnatal development

FL Portillo Pacheco, B Moreno López - 2020 - rodin.uca.es
NO at neonatal stage induces loss of both excitatory and inhibitory boutons even though
findings: (1) it is well known that adult motor neurons do not express NOS (Moreno-López 2010)…

Artemisinin facilitates motor function recovery by enhancing motoneuronal survival and axonal remyelination in rats following brachial plexus root avulsion

S Chen, L Wu, B He, G Zhou, Y Xu, G Zhu… - Acs Chemical …, 2021 - ACS Publications
… BPI causes the devastating MN death and the permanent … after injury, MNs have no other
choice but to strive to survive … prevent motoneuron death following spinal root avulsion in adult

Events occurring in the axotomized facial nucleus

K Nakajima, T Ishijima - Cells, 2022 - mdpi.com
… , is induced in motoneurons in the axotomized facial nucleus [… Axotomized facial motoneurons
of newborn rats are known to … Although most motoneurons survived in axotomized adult rat …

Expression of ChAT, Iba-1, and nNOS in the Central Nervous System following Facial Nerve Injury

JM Lee, MC Yoo, YJ Kim, SS Kim, SG Yeo - Antioxidants, 2024 - mdpi.com
… caused by facial nerve axotomy induces increased NOS production in motor neurons [19]. …
between the reduction in motor neurons after axotomy in neonatal mammals and NOS …

Quercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus …

Y Huang, X Zhang, Q Huang, Y Dou, C Qu… - Inflammation and …, 2022 - Springer
induced in spinal motoneurons by root avulsion lesion in adult rats, and that the induction of
… thought to play a crucial role in inducing axotomized spinal cord motoneuron death [41, 85,…

Central Facial Nervous System Biomolecules Involved in Peripheral Facial Nerve Injury Responses and Potential Therapeutic Strategies

JM Lee, YJ Choi, MC Yoo, SG Yeo - Antioxidants, 2023 - mdpi.com
… after facial nerve axotomy in adult rats, and … axotomy-induced apoptosis and death of CNS
neurons; consistent with this, the survival rate of axotomized hippocampal and motor neurons