… drug resistant TB (pre-XDRTB) and extensively drug-resistant TB (XDR-TB), rare types of
MDR-TB … with and without albumin, validating azaaurones as potent antimycobacterial agents. …

… the existence of compounds with potent in vitro activity [2]. … cytotoxic agents, we decided
to focus on azaaurones where … the design of leishmanicidal and antibacterial agents [23,24,…

… group discovered that azaaurone based scaffold displays optimal antimycobacterial activity,
… Moreover, 6.2% of MDR-TB cases represent extensively-resistant TB (XDRTB) that include …

… TB drugs. Simpler drug regimens that are safe, well tolerated, and effective against MDR/XDR
TB … We selected two azaaurone leads and two aurone leads that had high SIs on the three …

… aza-aurones. Firstly, the intermediate spiropyrazolines were obtained through a highly
regioselective 1,3-dipolar cycloaddition of nitrilimines with aza-aurones. … Aza-aurones 1 was used …

… resistance to strong first-line anti-TB drugs (isoniazid and … for the treatment of drug-resistant
TB, seem to have become … The mechanism of action of azaaurones still remains unclear…

… In this context, azaaurones were investigated as anticancer agents [72] and antibacterial
and … Interestingly, azocanes were also reported as potent dual NK1 receptor antagonist-…

… , high kinetic solubility, and improved antimycobacterial activity (in the sub-micromolar range…
to azaaurone appeared to be suitable for developing compounds with potent antiviral activity…

… and hemithioindigos (sometimes azaaurones and thioaurones, … indanone derivative with
strong antiproliferative activity (IC … back the quest for new antibacterial agents to the forefront of …

… Citation 22 The natural alkaloid Phaitanthrin-A isolated from Phaius mishmensis, which
appears to be potent inhibitor of the life cycle of toxoplasma gondii with low host cell cytotoxicity ( …