… In the search for new SIRT inhibitors from marine sponges, from this species, Nakamura et
al… this marine organism, Nakao et al. [65] isolated five cyclic tetrapeptides named azumamides …

… that azumamide C was a two-fold more potent inhibitor than … Gottesfeld; Cyclic tetrapeptide
HDAC inhibitors as potential … SIRT1–3 inhibitory steroid sulfates from a marine sponge of the …

… into naturally occurring cyclic peptides in HDAC inhibition. … Romidepsin is a type I histone
deacetylase (HDAC) inhibitor [… the construction of the cyclic tetrapeptide via PMB deprotection …

… Azumamides A–E were the first cyclic peptides with HDAC inhibitory activity isolated from
marine … in the myelogenous leukemia K562 cell line, were isolated from a marine sponge of the …

… Azumamides A (1) and E (2) were two cyclotetrapeptides isolated from the marine sponge
… been demonstrated to exhibit potent inhibitory activities against histone deacetylase (HDAC) …

… to this study, the azumamides (Fig. 6, compounds 6.5 and 6.6) [75, 76]. Combinatorial
libraries of cyclic α 3 β-tetrapeptides furnished two novel inhibitor scaffolds (compounds 7.3 and …

… , their derivative inhibitors of histone deacetylases, and their … of the cell cycle by inhibiting
histone deacetylation at very low … FR235222 (azumamide E) was also extracted from the …

… are linear, cyclic-macrocyclic, branched-cyclic, branched-… NRPs obtained from marine
organisms (sponges, tunicates, … various NRPs isolated from marine sponges and tunicates. …

… benefits of natural cyclic tetrapeptide inhibitors are unbossomed … full histone deacetylase
inhibitory profiling of azumamides AE as well as β²- epiazumamide E and β³-epi-azumamide E. …

… , inducing death, apoptosis, and cell cycle arrest in cancer cells. Recently, … The cyclic
tetrapeptide HDACis are made up of 12 or 13 residues, among … Marine sponge mycale izuensis …