… eventually abolish the MMP activity, we treated HEK293T cells expressing wt or BMP15 p.R329C …
R329C change we observed a severe reduction of luciferase reporter activation with …

… (a factor closely related to BMP15) is highly expressed in the … activity and the transcription of
Id1 and Smad7 target genes. … of-function mutation linked to acromesomelic chondrodysplasia…

… deleterious effects, such as reduced GCs growth, mature … activity and dominant negative
effect on wild type action, as the … -coding genes (TSH, LH, and FSH), co-expression with BMP15 …

… regulating physical activities by controlling various target genes. … decreased expression
levels of other genes associated with … Moreover, homozygous BMP15 mutations are also …

… They evaluated the expression and activity of 10 BMP15 variants and showed that these
nucleotide changes could reduce mature peptide production, activity or synergy with GDF9 [26]. …

… The majority of these defects were found in autosomal genes related to oogenesis and … [31]
have shown by expressing DAZL with recombinant human GDF9 and BMP15 that embryonic …

… ), bone morphogenetic protein 15 (BMP15), and growth … (4) 740YP administration increase
PI3K activity, whereas PTEN … resulted in expression of key Hippo signaling genes and an …

… Primary ovarian insufficiency (POI) is determined by … We identified 107 genes related to POI
etiology in mammals … A collective mouse model of several genes expressed in ovarian germ …

… predicted damage function and 32 mutations linked to the POI … of mutations on BMP15
expression, we transfected BMP15 … in POI patients, caused a reduction in the activity of the mature …

… (POI) is defined as a loss of ovarian activity before the age of … in the coding exons and
abutting splice sites of BMP15 (… modulate the expression of certain genes involved in POI. …