[HTML][HTML] Signaling pathways regulating thermogenesis

C Tabuchi, HS Sul - Frontiers in endocrinology, 2021 - frontiersin.org
BMP7 activates brown adipose tissue and reduces diet-induced obesity only at
subthermoneutrality. PloS One (2013) 8(9):e74083. doi: 10.1371/journal.pone.0074083 …

Wu-Mei-Wan prevents high-fat diet-induced obesity by reducing white adipose tissue and enhancing brown adipose tissue function

F Wu, X Yang, M Hu, Q Shao, K Fang, J Li, Y Zhao… - Phytomedicine, 2020 - Elsevier
… translocates into the nucleus and activates expression of target genes. Obese mice showed
a reduction of BMP7 in our study, WMW treatment significantly increased the expression of …

[HTML][HTML] AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity

E Casana, V Jimenez, C Jambrina, V Sacristan… - … Therapy-Methods & …, 2022 - cell.com
… mice with liver-directed AAV-BMP7 vectors enabled a long-lasting increase … BMP7
concentration induced browning of white adipose tissue (WAT) and activation of brown adipose

Brown Adipose Tissue in Obesity and Diabetes

M Alcalá, L Herrero, D Serra, M Viana - Obesity and Diabetes: Scientific …, 2020 - Springer
… , only two reports have evaluated BAT activation using this … , obesity, and diabetes have
been associated with a decrease … also plays a key role in diet-induced thermogenesis. Efforts to …

[HTML][HTML] Two-step regulation by matrix Gla protein in brown adipose cell differentiation

L Zhang, X Cai, F Ma, X Qiao, J Ji, JA Ma, L Vergnes… - Molecular …, 2024 - Elsevier
BMP7 and is expressed in endothelial and progenitor cells. The objective was to determine
the role of MGP in brown adipose tissue (… Noggin was also reduced in diet-induced obesity in …

[HTML][HTML] Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes

Y Guo, Z Wan, P Zhao, M Wei, Y Liu, T Bu… - Journal of …, 2021 - Springer
… to explore whether SmartExo@Bmp7 induce adipose browning in obese mice. Mice … BMP7
activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality

[HTML][HTML] Silk hydrogel-mediated delivery of bone morphogenetic protein 7 directly to subcutaneous white adipose tissue increases browning and energy expenditure

KL Townsend, E Pritchard, JM Coburn… - … in bioengineering and …, 2022 - frontiersin.org
… for BMP7 in order to mimic our prior in vitro brown adipocyte … In diet-induced obese mice,
BMP7-loaded silk delivery to … weight gain, reduced circulating glucose and lower respiratory …

[PDF][PDF] Studying brown fat in the thermoneutral animal

P Aldiss - eprints.nottingham.ac.uk
decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy
humans. Obesity … fat metabolism on brown adipose tissue in mice with diet-induced obesity. Ann …

[HTML][HTML] Bone morphogenetic proteins (BMPs) in the central regulation of energy balance and adult neural plasticity

GS Jensen, NE Leon-Palmer, KL Townsend - Metabolism, 2021 - Elsevier
… 1A (BMPR1A), in reducing body weight by modulating … Activation of the SMAD pathway
begins with phosphorylation … In this study, BMP7 treatment of hypothalamic neuronal cells

[HTML][HTML] Impact of adaptive thermogenesis in mice on the treatment of obesity

M Bastías-Pérez, S Zagmutt, MC Soler-Vázquez… - Cells, 2020 - mdpi.com
… In the last decade, brown adipose tissue has become an … This mechanism of diet-induced
thermogenesis is mediated by … Therefore, approaches to activate BAT and reduce glucose and …