Glutamate metabolism in mitochondria is closely related to alzheimer's disease

J Song, X Yang, M Zhang, C Wang… - Journal of Alzheimer's …, 2021 - content.iospress.com
… through glycolysis, and then pyruvate enters the mitochondria … AAT is expressed as two
isozymes in the brain, mitochondrial … a connection between nerve cells and mitochondrial activity …

Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury

WB Hubbard, ML Spry, JL Gooch, AL Cloud… - Brain, 2021 - academic.oup.com
… were then isolated from the ipsilateral cortex at 2 and 7 days post-injury and mitochondrial
… This could potentially signify a decrease in oxidative phosphorylation in glia due to glycolytic

Mitochondrial function and brain Metabolic Score (BMS) in ischemic Stroke: Evaluation of “neuroprotectants” safety and efficacy

A Mayevsky, H Kutai-Asis, M Tolmasov - Mitochondrion, 2020 - Elsevier
… The breakdown of glucose into water and CO 2 includes two steps, namely, glycolysis (…
mitochondria. Of the total yield of 38 ATP per mole of glucose, 2 are produced in the glycolysis

Rescuing mitochondria in traumatic brain injury and intracerebral hemorrhages-A potential therapeutic approach

M Ahluwalia, M Kumar, P Ahluwalia, S Rahimi… - Neurochemistry …, 2021 - Elsevier
… An average adult human brain weighs about 2% of total body weight. But it consumes about
20% of oxygen supply of the body to sustain its high rate of metabolic activity (Agranoff and …

Blood–brain barrier and neurovascular unit in vitro models for studying mitochondria-driven molecular mechanisms of neurodegeneration

AB Salmina, EV Kharitonova, YV Gorina… - International Journal of …, 2021 - mdpi.com
… : inhibition of glycolysis and mitochondrial respiration as a … activity may contain up to 2
million mitochondria [14]; so, the … , mitochondria transfer or metabolites action in relation to NVU …

Peripheral glycolysis in neurodegenerative diseases

SM Bell, T Burgess, J Lee, DJ Blackburn… - International journal of …, 2020 - mdpi.com
… Overall glycolysis produces a net of 4 molecules of ATP and twoGlycolysis can be directly
observed in the human brain using … the rate of glycolysis and mitochondrial function may also …

Comparison of effects of metformin, phenformin, and inhibitors of mitochondrial complex I on mitochondrial permeability transition and ischemic brain injury

K Skemiene, E Rekuviene, A Jekabsone, P Cizas… - Biomolecules, 2020 - mdpi.com
… (hypoxia plus DOG to inhibit glycolysis) on cell viability in brain slice cultures prepared from
… cause differences on Ca 2+ - induced MPTP regulation in isolated brain mitochondria. The …

Brain energy metabolism and multiple sclerosis: progress and prospects

SJ Park, JW Choi - Archives of Pharmacal Research, 2020 - Springer
… the relationship between MS and metabolism in the brain is yet … The two major pathways for
energy production, glycolysis … Energy production in the mitochondria occurs in two steps. First…

[HTML][HTML] Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders

IM Morella, R Brambilla, L Morè - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Brain mitochondria are considered crucial mediators of … Pyruvate, the product of glycolysis,
and fatty acids are … of the reducing equivalents NADH and FADH 2 . These coenzymes carry …

Coupling of GABA metabolism to mitochondrial glucose phosphorylation

JP Cavalcanti-de-Albuquerque… - Neurochemical …, 2021 - Springer
… and is coupled to the brain mitochondrial redox modulation by … shunt stimulated mitochondrial
O 2 consumption and H 2 O 2 … -mediated regulation of glycolytic pace are poorly explored. …