[HTML][HTML] BRIE2: computational identification of splicing phenotypes from single-cell transcriptomic experiments

Y Huang, G Sanguinetti - Genome biology, 2021 - Springer
… of splicing phenotypes within the splicing quantification task … the splicing ratio from a set
of features associated with cell-… By default in brie-quant, we filter out events with (1) less than …

Computational identification of splicing phenotypes from single cell transcriptomic experiments

Y Huang, G Sanguinetti - biorxiv, 2020 - biorxiv.org
… of splicing phenotypes within the splicing quantification task itself… the splicing ratio from a set
of features associated with cell-… By default in brie-quant, we filter out events with 1) less than …

[HTML][HTML] Single-cell alternative splicing analysis reveals dominance of single transcript variant

W Liu, X Zhang - Genomics, 2020 - Elsevier
single cells tend to express one major transcript variant of a gene, and the diversity of transcript
variants in cell … Therefore, we believe that BRIE is not suitable for testing the cell model …

[PDF][PDF] Single-cell transcriptomic analysis reveals dynamic alternative splicing and gene regulatory networks among pancreatic islets

Y Li, J Chen, Q Xu, Z Han, F Tan, T Shi… - Science China Life …, 2021 - researchgate.net
… Figure 1 Alternative splicing and gene regulatory network profiles of pancreatic islet … BRIE:
transcriptome-wide splicing quantification in single cells. Genome Biol 18, 123. Lee, Y., and …

[HTML][HTML] Technological advances and computational approaches for alternative splicing analysis in single cells

WX Wen, AJ Mead, S Thongjuea - Computational and structural …, 2020 - Elsevier
… the first time, characterization of transcriptome-wide exon-level alternative splicing events at
the … In addition to characterizing exclusion and inclusion rates across identical cells, BRIE is …

MARVEL: an integrated alternative splicing analysis platform for single-cell RNA sequencing data

WX Wen, AJ Mead, S Thongjuea - Nucleic Acids Research, 2023 - academic.oup.com
… analyze splicing dynamics at single-cell resolution. Here, we present MARVEL, a comprehensive
R package for single-cell splicing analysis … For BRIE, differential splicing analysis was …

[HTML][HTML] Interrogations of single-cell RNA splicing landscapes with SCASL define new cell identities with physiological relevance

X Xiang, Y He, Z Zhang, X Yang - Nature Communications, 2024 - nature.com
… , BRIE 18 (for single-cell data) and Expedition 19 (for single-… each single cell, generating
an AS probability matrix representing the transcriptome-wide landscape of splicing at single-cell

[HTML][HTML] Single-cell differential splicing analysis reveals high heterogeneity of liver tumor-infiltrating T cells

S Liu, B Zhou, L Wu, Y Sun, J Chen, S Liu - Scientific Reports, 2021 - nature.com
… However, BRIE requires performing a pairwise comparison between every two … a single
cell dataset from CRC patients. Thus, systematic evaluation of differential splicing across T cells

Integrative analysis of proteome-wide association and transcriptome-wide association study identifies candidate brain proteins associated with insomnia

P Meng, B Cheng, H Zhang, S Cheng, L Liu, X Yang… - 2021 - researchsquare.com
Transcriptome-wide association study (TWAS) was then used to verify the results at the DNA
level. Finally, brain imaging GWAS was used to explore the brain functional areas related to …

scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data

X Wu, T Liu, C Ye, W Ye, G Ji - Briefings in Bioinformatics, 2021 - academic.oup.com
… for characterization of spliced isoforms in single cells, such as Expedition [63], BRIE [64] …
heterogeneity in APA isoform usages on a transcriptome-wide scale. scAPAtrap proposed in this …