Combined therapy of ATRA and imatinib mesylate decreases BCR-ABL and ABCB1/MDR1 expression through cellular differentiation in a chronic myeloid leukemia …
CA Pinto, AJS Portilho, MC Barbosa, MEA De Moraes… - in vivo, 2021 - iv.iiarjournals.org
… The expression of BCR-ABL gene and multidrug resistance … The next step was to evaluate
the gene expression levels of … of cancer cells to chemotherapy, which can be a determining …
the gene expression levels of … of cancer cells to chemotherapy, which can be a determining …
Detection of mutations in CML patients resistant to tyrosine kinase inhibitor: imatinib mesylate therapy
N Karasu, H Akalin, N Gokce, A Yildirim, M Demir… - Medical Oncology, 2021 - Springer
… have no response to imatinib therapy this rate is rising 15.6%. … aim was to determine the
mutations of the BCR/ABL and to … that increased BCR/ABL mRNA levels detected by RT-qPCR (…
mutations of the BCR/ABL and to … that increased BCR/ABL mRNA levels detected by RT-qPCR (…
Evaluation of molecular response to imatinib mesylate treatment in Iranian patients with chronic myeloid leukemia
L Nekoohesh, S Rostami, M Nikbakht… - … Myeloma and Leukemia, 2020 - Elsevier
… resistance or intolerance were not included in this study); and (6) at least 2 BCR-ABL transcript
level … methods were used to determined BCR-ABL transcript levels. The results of patients…
level … methods were used to determined BCR-ABL transcript levels. The results of patients…
A small molecule inhibitor, OGP46, is effective against imatinib-resistant BCR-ABL mutations via the BCR-ABL/JAK-STAT pathway
L Wei, Y Yang, P Gupta, A Wang, M Zhao… - Molecular Therapy …, 2020 - cell.com
… We next determined the long-term efficacy of OGP46 on the … of action of OGP46 on mRNA
expression by mRNA sequencing (… Similarly, the expression levels of 551 and 109 genes were …
expression by mRNA sequencing (… Similarly, the expression levels of 551 and 109 genes were …
Evaluation of Imatinib Concentrations in Samples Submitted for BCR-ABL1 or Imatinib Testing—Evidence to Support Therapeutic Drug Monitoring for Dose …
L Smy, AJ Sadler, GA McMillin - Therapeutic drug monitoring, 2020 - journals.lww.com
… TKI developed was imatinib mesylate (imatinib, Gleevec, … test to determine the potential
for imatinib resistance due to … have occurred because samples for BCR-ABL testing were not …
for imatinib resistance due to … have occurred because samples for BCR-ABL testing were not …
Overexpression of P‐glycoprotein and resistance to Imatinib in chronic myeloid leukemia patients
M Ammar, N Louati, I Frikha… - Journal of Clinical …, 2020 - Wiley Online Library
… the P-gp expression level on lymphocytes from Tunisian … Imatinib mesylate (IM) is the
first molecule tyrosine kinase … widely divided into BCR-ABL-dependent or BCR-ABL-independent. …
first molecule tyrosine kinase … widely divided into BCR-ABL-dependent or BCR-ABL-independent. …
Relationship between trough level of tyrosine kinase inhibitor (imatinib and nilotinib) and BCR-ABL ratios in an Indonesian chronic-phase chronic myeloid leukemia …
… Imatinib mesylate is the first generation of TKI, which can induce … This study was conducted
to determine the relationship … that are resistant to imatinib due to BCR-ABL mutations, except …
to determine the relationship … that are resistant to imatinib due to BCR-ABL mutations, except …
The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia
H Losson, SR Gajulapalli, M Lernoux, JY Lee… - Pharmacological …, 2020 - Elsevier
… of imatinib and could overcome TKI resistance in CML cells. … 7b on BCR-ABL expression
and on α-tubulin acetylation levels in … To assess adverse effects, we also performed histological …
and on α-tubulin acetylation levels in … To assess adverse effects, we also performed histological …
Alterations in sialylation patterns are significantly associated with imatinib mesylate resistance in chronic myeloid leukemia
KD Patel, M De, DD Jethva, BS Rathod… - Archives of Medical …, 2022 - Elsevier
… and ST3GAL2 levels with IM resistance in … levels and leukemia during pre-IM era (28,29),
our findings presented circulatory TSA levels as a candidate marker to determine IM resistance …
our findings presented circulatory TSA levels as a candidate marker to determine IM resistance …
Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line
JB Willig, DRB Vianna, A Beckenkamp… - Purinergic …, 2020 - Springer
… with imatinib mesylate, which selectively inhibits the BCR-ABL … , mRNA levels of ENTPD
and NT5E were determined. The K-… in the resistant phenotype, where the imatinib mesylate is …
and NT5E were determined. The K-… in the resistant phenotype, where the imatinib mesylate is …